Fig 1: ROC curve analysis of C3, CFB, CLU, CALR, and NE for distinguishing pSjD from non-pSjD. The ROC curves show the discrimination between pSjD and non-pSjD participants based on salivary C3, CFB, CLU, CALR, and NE. Area under the curve (AUC) for each ROC curve is shown in the figure. pSjD, primary Sjögren’s disease; C3, Complement C3; CFB, Complement factor B; CLU, Clusterin; CALR, Calreticulin; NE, Neutrophil elastase; AUC, area under the curve
Fig 2: Comparisons of uSFR, sSFR, and ESSDAI score between high- and low-level salivary biomarker groups. The 121 pSjD patients were divided into high-level and low-level groups based on the cut-off value. uSFR, sSFR and ESSDAI score were compared between high- and low-level salivary biomarker groups. Mann-Whitney U test was used to analyze data for differences. Data are representative of 3 independent experiments. *, P < 0.05, **, P < 0.01, ***, P < 0.001, ****, P < 0.0001. C3, Complement C3; CFB, Complement factor B; CLU, Clusterin; NE, Neutrophil elastase; CALR, Calreticulin; uSFR, unstimulated salivary flow rate; sSFR, stimulated salivary flow rate; ESSDAI, EULAR Sjögren’s Syndrome Disease Activity Index
Fig 3: The differences in levels of C3, CFB, CLU, CALR, and NE between pSjD and non-pSjD groups. The concentration of C3 (A), CFB (B), CLU (C), NE (D), and CALR (E) in saliva samples from pSjD (n = 121) and non-pSjD (n = 65) groups. Mann-Whitney U test was used to analyze data for differences Data are representative of 3 independent experiments. *, P < 0.05, **, P < 0.01, ***, P < 0.001, ****, P < 0.0001. pSjD, primary Sjögren’s disease; C3, Complement C3; CFB, Complement factor B; CLU, Clusterin; CALR, Calreticulin; NE, Neutrophil elastase
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