Fig 1: Effects of WYD on enteral transit rate and serological parameters in mice with LIA. (A) Enteral transit ratio; (B) MTL; (C) Gas; (D) SP; (E) AChE; and (F) VIP in mice with LIA by ELISA. Contradistinguished with the No group, #, P<0.05, ##, P<0.01; compared with the Lop + Saline group, *, P<0.05, **, P<0.01. Mice were grouped as follows: No: NC group; Lop + Saline: Lop and saline were used to cure the mice; Lop + WYD-L: Lop and WYD at 10.2 g/kg BW were used to cure the mice; Lop + WYD-M: Lop and WYD at 20.4 g/kg BW were used to cure the mice; Lop + WYD-H: Lop and WYD at 40.8 g/kg BW were used to cure the mice; Lop + Pur: Lop and prucalopride at 0.26 mg/kg BW were used to cure the mice. Lop, loperamide; WYD, Wenyang Yiqi Decoction; Pru, prucalopride; LIA, loperamide-induced astriction; MTL, motilin; Gas, gastrin; SP, substance P; AChE, acetylcholinesterase; VIP, vasoactive intestinal peptide; ELISA, enzyme-linked immunosorbent assay; BW, body weight.
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