Fig 1: Serum bone turnover biomarkers in OVX, ORX and control groups one-month post-gonadectomy. (A) Estradiol level in the female sham and OVX group; (B) testosterone level in the male sham and ORX group; (C) PINP level; (D) OCN level; (E) CTX level. *P<0.05, ***P<0.001 when compare to sham group. ###P<0.001 when compare to M-sham group. Five mice per group were analyzed. All data were presented as the mean ± standard deviation. FM, female; OVX, ovariectomy; M, male; ORX, orchiectomy; PINP, propeptide of type I procollagen; OCN, osteocalcin; CTX, C-terminal telopeptide.