Fig 1: Effects of STAT3 knockdown on ciglitazone (Ci) abilities under Rhinovirus infection conditions. Rhinovirus 16 (H16 in the Figure, major serotype) and 2 (H2 in the Figure, minor serotype) and were used. In comparison to the conditions without the knockdown, the MMP-9 (A) and TGF-ß (B) mRNA expressions were decreased. Ciglitazone effect were observed in COL mRNA expression, especially its decreasing effect on HRV-induced COL and a-SMA expression (C, E). No effect of ciglitazone was observed in ADAM33 (D). *p < 0.05 in comparison to the control sample, +p < 0.05 in comparison to the Rhinovirus sample (HRV-2 or HRV-16, respectively). Ciglitazone (Ci) has been added before rhinovirus infection (Ci+H16, Ci+H2) or after rhinovirus infection (H16+Ci, H2+Ci). C – control sample with medium only.