Fig 1: Effects of STAT3 knockdown on ciglitazone (Ci) abilities under Rhinovirus infection conditions. Rhinovirus 16 (H16 in the Figure, major serotype) and 2 (H2 in the Figure, minor serotype) and were used. In comparison to the conditions without the knockdown, the MMP‐9 (A) and TGF‐β (B) mRNA expressions were decreased. Ciglitazone effect were observed in COL mRNA expression, especially its decreasing effect on HRV‐induced COL and a‐SMA expression (C, E). No effect of ciglitazone was observed in ADAM33 (D). *p < 0.05 in comparison to the control sample, +p < 0.05 in comparison to the Rhinovirus sample (HRV‐2 or HRV‐16, respectively). Ciglitazone (Ci) has been added before rhinovirus infection (Ci+H16, Ci+H2) or after rhinovirus infection (H16+Ci, H2+Ci). C – control sample with medium only.