Fig 1: Proliferation analyses in CCM3 KO/WT iEC co-cultures under VEGFA or bevacizumab treatment. A, B Co-cultures of CCM3 KO and WT iECs were treated with different concentrations of vascular endothelial growth factor A (VEGFA) (A) or bevacizumab (B) and analyzed after six days to evaluate dose-dependent effects on cell proliferation. DMSO-treated co-cultures were used as controls. Representative fluorescence images (scale bar = 500 μm) and proportion of CCM3 KO cells normalized to the DMSO control and presented as means and SD (n = 3) are shown. One-way ANOVA followed by Dunnett’s multiple comparisons test was used for statistical analysis