Fig 1: Comparison of plasma protein concentrations between mining region residents (MRR) and non-mining region residents (NMR). Box plots show that plasma levels of NFKB1 (A) and CDKN2A (B) were significantly higher in the MRR group compared to the NMR group. No significant group differences were observed for IGF2 (C)and APOA5 (D).
Fig 2: Added-variable (AV) plots showing significant associations between DNA methylation, mRNA expression, metal exposure, and plasma protein levels for NFKB1 (A–C) and IGF2 (D–G). All numeric point labels automatically generated by the avPlot() function have been removed for clarity. All AV plots are based on the combined dataset (MRR + NMR), and each panel now includes explicit labeling to indicate whether the comparison involves MRR, NMR, or both (A–B) NFKB1 protein levels were significantly associated with DNA methylation levels at chr4:102501416 (A) and chr4:102501517 (B). (C) NFKB1 protein levels were higher in mining region residents (MRR). (D) IGF2 protein levels were positively associated with its transcript expression and (E) positively associated with the cumulative Z-score of essential metal concentrations. (F–G) IGF2 protein levels were higher in males (F) and positively associated with age (G).
from Biorbyt for Human IGF2 ELISA Kit
Application Notes: serum, plasma, tissue homogenates, cell lysates and other biological fluids.