Fig 1: Components of the renin-angiotensin-aldosterone system. The renin-angiotensin-aldosterone system and its main effects are depicted in (A). Components of the renin-angiotensin-aldosterone system; soluble angiotensin-converting enzyme-2 (sACE2; B, C), angiotensin-converting enzyme (ACE; D), angiotensin-II (Ang-II; E, F), angiotensin 1–7 (Ang 1–7; G) and angiotensin 1–9 (Ang 1–9; H) were determined in blood samples at hospital admission (Adm) and discharge (Dis). The variations of sACE2 (C) and Ang-II (F) from admission to discharge were determined. *p < 0.05; #p < 0.05 vs. severe at admission; &p < 0.05 vs. severe at discharge.