Fig 2: Kaplan–Meier survival curves for progression-free survival (PFS) based on: (A) PVR gene expression, (B) PVR serum level, (C) Serum amylase, (D) Urinary IGFBP-7/creatinine, and (E) Urinary TIMP-2/creatinine. Log-rank p-values are indicated for each comparison

Fig 3: Kaplan–Meier survival curves for overall survival (OS) based on: (A) PVR gene expression, (B) PVR serum level, (C) Serum amylase, (D) Urinary IGFBP-7/creatinine, and (E) Urinary TIMP-2/creatinine. Log-rank p-values are indicated for each comparison

Fig 4: Receiver Operating Characteristic (ROC) curves showing diagnostic performance of: (A) PVR gene expression, (B) PVR serum level, (C) Serum amylase, (D) Urinary IGFBP-7/creatinine, and (E) Urinary TIMP-2/creatinine. Area under the curve (AUC), sensitivity, and specificity values are presented

Fig 5: Endothelial IGFBP7 expression is downregulated in a stage-specific manner during inflammation-driven carcinogenesis. A Schematic diagram showing the timeline for mouse euthanasia at different time points in the AOM/DSS-induced colitis-associated CRC model. Created with BioRender.com. B PCA analysis of transcriptome sequencing in mouse colon tissue. C Representative immunofluorescence images of IGFBP7 expression in endothelial cells of mice at different time points (scale bar, 50 μm). D, E Fluorescence intensity statistics of IGFBP7 expression in endothelial cells of mice at different time points. F, G Flow cytometry analysis statistics of IGFBP7 expression in endothelial cells of mice at different time points. H Pseudo-time analysis of AOM/DSS model mouse colon tissue from T1 to T4 stages based on Mfuzz. I Enrichment analysis of genes in Cluster 7. J Schematic representation of the AOM/DSS-induced colitis-associated colorectal cancer model in Igfbp7fl/fl; Cdh5-Cre+/− mice. Created with BioRender.com. K Colon length of Igfbp7fl/fl; Cdh5-Cre+/− mice following AOM/DSS treatment. L Tumor number in the colon of Igfbp7fl/fl; Cdh5-Cre+/− mice following AOM/DSS treatment