Fig 1: Effect of ticagrelor on pro-inflammatory chemokines and NLRP3 in AIA rat model. A RANTES/CCL5. B MIP-1α/CCL3, C Eotaxin-3 /CCL26 D NLRP3 using ELISA analysis. First Bar represents the control group, Second Bar represents the AIA group, Third Bar represents the Ticagrelor group and Fourth Bar represents the Ticagrelor + AIA group. E Correlation analysis between NLRP3 and all chemokine markers. Ticagrelor was given orally (30 mg/kg) for 21 days, AIA was induced by FCA (0.1 ml single dose S.C.). The left hind paws of rats from each group were separated on (day 22) then kept at -80°C for RANTES/CCL5, MIP-1α/CCL3, Eotaxin-3/CCL26 and NLRP3 ELISA analysis. Two-way ANOVA with Tukey-Kramer post hoc testing was employed for statistical analysis. Data are provided as means ± SD; p ≤ 0.05. (ns) non-significance, *p < 0.05. ****p < 0.0001. Correlation analysis was implemented based on Pearson’s correlation coefficient