Fig 1: The changes in specific airway resistance values (sRaw) after administration of NaV1.7 and NaV1.8 blockers in physiological conditions. sRaw values are expressed as means ± S.E.M. N—measurement before drug administration; 60 and 240—minutes after drug administration; (A) of Figure 2—ProTx III; (B)—huwentoxin IV; (C)—A803467. For more detailed explanation, see the legend of Figure 1. * p < 0.05, ** p < 0.01 and *** p < 0.001 vs. OVA−.
Fig 2: Changes in expression of isoforms NaV1.7 and NaV1.8 before (OVA−) and after development of chronic allergic inflammation (OVA+). Number of animals for each group: 7; * p < 0.05 vs. OVA−.
Fig 3: The changes in specific airway resistance values (sRaw) after administration of NaV1.7 and NaV1.8 blockers in allergic conditions. sRaw values are expressed as means ± S.E.M. sRaw values are expressed as averages ± SDs. N—measurement before drug administration; 60 and 240—minutes after drug administration; (A) of Figure 3—ProTx III; (B)—huwentoxin IV; (C)—A803467. For further detailed explanation, see legend of Figure 1. + p < 0.05, ++ p < 0.01 and +++ p < 0.001 vs. OVA+.
Fig 4: The changes in specific airway resistance values (sRaw) after the administration of the NaV1.8 blocker alone and with salbutamol/ipratropium in chronic inflammatory conditions. sRaw values are expressed as means ± S.E.M, and N means measurement before any drug administration; 60 and 240 are the minutes after the administration of a particular drug; A—A803467 concentration of 10−8 mols/L; A + S—A803467 + salbutamol concentration of 4 × 10−3 mols/L; A + I—A803467 + ipratropium concentration of 10−3 mols/L. Number of animals for each group: 7; + p < 0.05, ++ p < 0.01 and +++ p < 0.001 vs. OVA+. # p < 0.05 vs. salbutamol.
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