Fig 1: Concentration (Y-axis) of selected proteins (SYNCRIP, PLD3, C4, CTSD and SPP1) measured by ELISA in CSF samples of healthy controls (n = 12) and preclinical (n = 5) and clinical (n = 13) scrapie-infected sheep. The boxes are drawn from the first quartile to the third quartile and the median is shown as a horizontal line inside the box. The whiskers extend from the box to the most extreme data point within 1.5 times the interquartile range, with the data points outside that range being considered potential outliers. Significant differences between groups were measured using one-way ANOVA test followed by Tukey HSD for multiple pairwise-comparisons or Kruskal-Wallis followed by Dunn’s test, for normally and non-normally distributed data, respectively. *p-value < 0.05, **p-value < 0.01, ***p-value < 0.001, ****p-value < 0.0001.