Description
Recombinant Moloney murine leukemia virus (MMLV) retroviral vectors serve as efficient viral vector tools for introducing genes permanently into a wide variety of dividing cells, and provide an alternative to modify primary T cells. Creative biolabs has developed retroviral CAR vector pMMLV CD70 (10B4) h(28ζ), which is constructed for the engineering of T cells to target human CD70. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-CD70 antibody linked to a CD28 transmembrane domain and CD3-zeta signaling domains. And the vector product was designed for the treatment of Multiple Myeloma