SignalSilence ® Beclin-1 siRNA I from Cell Signaling Technology

Product Specs
ItemSignalSilence ® Beclin-1 siRNA I
CompanyCell Signaling Technology
Price $369.00 Inquire
Catalog Number6222S
Quantity300 µl
TargetBeclin 1
NCBI Gene AliasesATG6, VPS30, beclin1
NCBI Full Gene Namebeclin 1
Research AreaAutophagy
ReactivityH
ApplicationssiRNA
TypesiRNA

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Cell Signaling Technology

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Danvers, Massachusetts 01923

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Phone: 877-616-CELL
Phone: 978-867-2388
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Website: http://www.cellsignal.com/

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(1) Hungatella hathewayi: A Tumor-Derived Bacterium Enriched in Colorectal Cancer Tissues and a Potential Diagnostic BiomarkerMicroorganismsMarch 21, 2026Wenzhe Zhang, Jin Liu, Shanshan Sha, Qiulong Yan, Yufang MaProteinTech Group, Inc.), HIF-1α (Cat. PB9253, Boster Biological Technology Co., Ltd., Wuhan, China), CDH1 (Cat. PTM-6222, PTM BioLab Inc., Hangzhou, China), Vimentin (Cat. PTM-5376, PTM BioLab Inc.), Snail1 (Cat. 3879, Cell Signaling Technology

(2) PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate Epithelial-Mesenchymal and Mitofusion-Fission Transitions in Colorectal CancerInternational Journal of Biological SciencesMarch 25, 2024Zi-Jia Huang, Yang-Jia Li, Jie Yang, Lei Huang, Qian Zhao, Yi-Fan Lu, Yang Hu, Wei-Xia Zhang, Jun-Ze Liang, Jinghua Pan, et al.(cat#3879), phospho-c-Raf (Ser338, cat#9427) was obtained from Cell Signaling Technology; E-Cadherin (cat#PTM-6222) was obtained from PTM BIO (Hangzhou, China); phospho-ERK1/2 (Phospho-ERK1-T202/Y204+ERK2-T185/Y187,

(3) Porcine epidemic diarrhoea virus (PEDV) infection activates AMPK and JNK through TAK1 to induce autophagy and enhance virus replicationVirulenceDecember 31, 2022Jingxiang Wang, Xianjin Kan, Xiaomei Li, Jing Sun, Xiulong XuLife Technologies (Invitrogen Life Technologies, Grand Island, NY, USA). TAK1 (#6317S), Beclin-1 (#6222S), and ATG5 (6345S) siRNA were purchased from Cell Signalling Technology (Danvers, MA, USA). Transfection

(4) Lomitapide, a cholesterol-lowering drug, is an anticancer agent that induces autophagic cell death via inhibiting mTORCell death & diseaseJuly 12, 2022Lee B, Park SJ, Lee S, Lee J, Lee E, Yoo ES, Chung WS, Sohn JW, Oh BC, Kim S.knock-down experiments, siATG7 (SignalSilence #6604; Cell Signaling Technology), siBeclin-1 (SignalSilence #6222; Cell Signaling Technology), siAMPK (siAMPK #1: 5′-CGACUAAGCCCAAAUCUUU-3′, siAMPK #2: 5′-ACCAUGAUUGAUGAUGAAGCCUUAA-3′)

(5) Blockade of Uttroside B-Induced Autophagic Pro-Survival Signals Augments Its Chemotherapeutic Efficacy Against Hepatocellular CarcinomaFrontiers in oncologyJanuary 1, 2022Nath LR, Swetha M, Vijayakurup V, Thangarasu AK, Haritha NH, Shabna A, Aiswarya SU, Rayginia TP, Keerthana CK, Kalimuthu K, et al.p70S6Kinase (2708S), p-4E-BP-1(2855S), 4E-BP-1(9452S), GAPDH (8884S), Akt (9272S) and Beclin siRNA (6222S), Caspase 9 (9508S), Caspase 8 (4790S), PARP (9532S), Cleaved PARP (5625S) were obtained from Cell Signaling Technologies

(6) Dual inhibition of DNA-PKcs and mTOR by CC-115 potently inhibits human renal cell carcinoma cell growthAgingOctober 27, 2020Zheng B, Sun X, Chen XF, Chen Z, Zhu WL, Zhu H, Gu DH.were provided by Santa Cruz Biotech (sc-29797, labeled as “siBeclin-1-a”) and Cell Signaling Tech (#6222, labeled as “siBeclin-1-b”) [33]. The scramble control siRNA (labeled as “siCtrl”) was provided by Santa

(7) The Use of Wood Biomass Ash in Sewage Sludge Treatment in Terms of Its Agricultural UtilizationWaste and Biomass ValorizationFebruary 1, 2020Marta Wójcik, Feliks Stachowicz, Adam Masłońmethod Spectrometric method, AAS PN-EN 15933:2013-02 [44] PN-EN 12880:2004 [45] PN-EN 14701-1:2007 [46] PN-EN ISO 6222:2004 [47] PN-EN 13657:2006 [48] CST capillary suction time, AAS atomic absorption spectrometry, cfu

(8) Molecular Mechanisms That Define Redox Balance Function in Pathogen-Host Interactionsâ€”Is There a Role for Dietary Bioactive Polyphenols?International Journal of Molecular SciencesDecember 10, 2019Kaiwen Mu, Danni Wang, David D. Kittseffector proteins to modulate cellular signaling pathways such as MAPK and Int. J. Mol. Sci. 2019, 20, 6222 4 of 18 2.2. Mechanisms for Microbial Effectors to Influence Host Cell Signaling Cell signaling processes

(9) Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress responseNature communicationsAugust 21, 2019Yang Y, Willis TL, Button RW, Strang CJ, Fu Y, Wen X, Grayson PRC, Evans T, Sipthorpe RJ, Roberts SL, et al.5′-GGAGUUGGAUCUCUCAGAA-3′; Atg5 siRNA (CST: #6345): 5′-GCCUGUAUGUACUGCUUUA-3′; Beclin 1 siRNA (CST: #6222): 5′-GGUCUAAGACGUCCAACAA-3′; Atg10 siRNA (Invitrogen): 5′-CCAUGGGACACUAUUACGC-3′; p62 siRNA (Eurofins):

(10) 5-Aminoimidazole-4-carboxamide ribonucleoside-induced autophagy flux during differentiation of monocytic leukemia cellsCell Death DiscoveryDecember 1, 2017Vilma Dembitz, Hrvoje Lalic, Dora Visnjicinterfering RNA (siRNA) SignalSilence Unconjugated Control (#6568), SignalSilence Beclin 1 siRNA I (#6222) and II (#6246), SignalSilence Atg7 siRNA I (#6604) were purchased from Cell Signaling Technology. ON-TARGETplus

(11) Synthetic lethal interaction of CDK inhibition and autophagy inhibition in human solid cancer cell linesOncology reportsJuly 1, 2017Okada Y, Kato S, Sakamoto Y, Oishi T, Ishioka C.and negative control siRNAs were purchased from Signal Silence, Cell Signaling Technology (#6345, #6222, and #6568). Each siRNA was introduced to the cell cultures to make a final concentration of 100 nM

(12) Polyphyllin G induces apoptosis and autophagy cell death in human oral cancer cellsPhytomedicine : international journal of phytotherapy and phytopharmacologyDecember 1, 2016Hsieh MJ, Chien SY, Lin JT, Yang SF, Chen MK.

(13) Anti-cancer effects of nitrogen-containing bisphosphonates on human cancer cellsOncotargetSeptember 6, 2016Jiang P, Zhang P, Mukthavaram R, Nomura N, Pingle SC, Teng D, Chien S, Guo F, Kesari S.

(14) RETRACTED ARTICLE: JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagyScientific ReportsDecember 17, 2014Xinbing Sui et al.siRNA (Qiagen,1027280), Atg5 siRNA (Qiagen, SI02655310), Beclin1 siRNA (Cell Signaling Technology, #6222) or JNK siRNA (Cell Signaling Technology, #6233) via LipofectAMINE RNAi max (Invitrogen, 13778150) according

(15) Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cellsPloS oneJanuary 1, 2014Li C, Chen J, Lu B, Shi Z, Wang H, Zhang B, Zhao K, Qi W, Bao J, Wang Y.obtained for MitoSciences (Eugene, Oregon, US). Small interfering RNAs (siRNAs) against human Beclin1(#6222), LC3(#6212) and control siRNA(#6568) were purchased from Cell Signaling Technologies, USA. Following

(16) Human placental trophoblasts confer viral resistance to recipient cellsProceedings of the National Academy of SciencesJuly 16, 2013Elizabeth Delorme-Axford et al.beclin-1, 40 nM per well of scrambled nontargeting siRNA (siControl) or Beclin-1 siRNA (Cell Signaling, #6222S) was transfected. Plasmid transfections were performed using X-tremeGENE 9 (Roche) according to the

(17) Autophagy Inhibition Enhances Daunorubicin-Induced Apoptosis in K562 CellsPLoS ONEDecember 2, 2011Weidong Han et al.RNA interference, two siRNA oligonucleotides targeting Beclin-1 were bought from Cell Signaling Tech (#6222 & 6246). A nonspecific oligo that is not complementary to any human genes was used as a negative control.

(18) Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52Nature communicationsJanuary 1, 0001"Jo C, Gundemir S, Pritchard S, Jin YN, Rahman I, Johnson GV."maintained at 33°C in a humidified atmosphere containing 5% CO2 for 24 h. The human beclin-1 specific siRNA (6222) was purchased from Cell Signaling Technology. Transient transfection and luciferase assays Cells

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