ML230 Focused-ultrasonicator from Covaris LLC

Product Specs
ItemML230 Focused-ultrasonicator
CompanyCovaris LLC
Price Get Pricing Get Quote for this Product
Catalog Number500656
Dimensions46.5 cm (width), 51.5 cm (depth), and 58.5 cm (height)
QuantityEA
ApplicationsDNA, RNA, Protein, and Biomarker extraction: DNA/ RNA Shearing for NGS
TypeFocused-ultrasonicator
Electrical Requirements100 to 240 VAC 500VA, 50 to 60Hz
Volume5 to 500 µL
Components8 AFA-TUBE TPX Strip 8 microTUBE-50 AFA Fiber H Slit Strip V2 8 microTUBE-130 AFA Fiber H Slit Strip V2 (12)
Temperature15 to 25 °C

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Covaris LLC

14 Gill St, Unit H

Woburn, Massachusetts 01801-1721

United States

Phone: +1 781-932-3959
Fax: +1 781-932-8705

Email: info@covaris.com

Company Profile

Website: www.covaris.com

(1) NeoCircle: pre- and post-operative circulating tumor DNA dynamics predicts survival in neoadjuvant-treated early breast cancerEMBO Molecular MedicineMay 26, 2026Anthony M George, Yilun Chen, Sergii Gladchuk, Miguel Alcaide, Hina Dalal, Pei Meng, Christian Brueffer, Hani Saghir, Siker Kimbung, Kristina Aaltonen, et al.instrument,Thermo Fisher Scientific,Q33327 E220 or ML230 Focused-ultrasonicator instrument,Covaris,"500239, 500656" QIAseq UDI Y-Adapter sequences,Qiagen,"180312, 180314, 180316, 180318" Pippin HT instrument,Sage

(2) Plasma cell identity escape drives resistance to anti-BCMA T-cell-redirecting therapy in multiple myelomabioRxivDecember 11, 2025Francesco Maura, Ciara L. Freeman, Kylee H Maclachlan, Marta Larrayoz Larrayoz Ilundain, Bachisio Ziccheddu, Erin W Meermeier, Juan-Jose Garces, Michael Durante, Holly Lee, Ross Firestone, et al.Universal Kit (Qiagen). For library preparation, 100 ng of genomic DNA was fragmented using the Covaris ML230 focused ultrasonicator (Covaris, Inc.), followed by library construction with the TruSeq DNA Nano Library Prep Kit (Illumina)

(3) Ultrasensitive Detection and Monitoring of Circulating Tumor DNA Using Structural Variants in Early-Stage Breast CancerClinical Cancer ResearchApril 14, 2025Mitchell J. Elliott, Karen Howarth, Sasha Main, Jesús Fuentes Antrás, Philippe Echelard, Aaron Dou, Eitan Amir, Michelle B. Nadler, Elizabeth Shah, Celeste Yu, et al.sonication to mimic the fragment size distribution of cfDNA using 8 AFA-TUBE TPX Strips (Covaris) and the ML230 Focused-ultrasonicator instrument (Covaris) by following the manufacturer’s protocol for fragmentation to the 175-bp target

(4) Ultrasensitive Detection and Monitoring of Circulating Tumor DNA Using Structural Variants in Early-Stage Breast CancerClin Cancer ResJanuary 9, 2025Mitchell J. Elliott, Karen Howarth, Sasha Main, Jesús Fuentes Antrás, Philippe Echelard, Aaron Dou, Eitan Amir, Michelle B. Nadler, Elizabeth Shah, Celeste Yu, et al.sonication to mimic the fragment size distribution of cfDNA using 8 AFA-TUBE TPX Strips (Covaris) and the ML230 Focused-ultrasonicator instrument (Covaris) by following the manufacturer’s protocol for fragmentation to the 175-bp target

(5) Enhancing Meningococcal Genomic Surveillance in the Meningitis Belt Using High-Resolution Culture-Free Whole-Genome SequencingThe Journal of Infectious DiseasesSeptember 4, 2022Mark Itsko, Nadav Topaz, Sani Ousmane-Traoré, Micheal Popoola, Rasmata Ouedraogo, Kadidja Gamougam, Adodo Yao Sadji, Abass Abdul-Karim, Christine Lascols, Xin Wangpreparation. Each DNA sample was diluted in 55 μL of 10 mM Tris buffer (pH 7.5) and fragmented by Covaris ML230 focused ultrasonicator (Covaris) to obtain an average size of 550 bp. The WGS libraries were prepared by NEBNext DNA Library Prep

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