X-CLARITY™ Polymerization System from Logos Biosystems

Product Specs
ItemX-CLARITY™ Polymerization System
CompanyLogos Biosystems
Price Get Pricing
Catalog NumberC20001
Quantity1 set
ThroughputUp to 768 samples
ApplicationsTissue Clearing
Dimensions(WxDxH) Exterior: 332 x 430 x 222 mm, Interior: 307 x 137 x 140 mm
TypeTissue clearing system
Electrical RequirementsAC 100 to 240 V, 50/60 Hz
TemperatureRT to 60°C
Interface5 in. capacitative touchscreen, 800 x 480 pixels
Weight28 kg
Components1 X-CLARITY™ Polymerization System 2 Heat Blocks (user's choice of two of the following: X-CLARITY™ Heat Block for 6 x 50 mL tubes & X-CLARITY™ Heat Block for flat-bottom plates)

Specifications/Features

Temperature Range RT to 60°C Vacuum Range -90 to 0 kPa

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Logos Biosystems

8F, 18 Gosan-ro 148beon-gil

Gunpo-si, Gyeonggi-do 15850

Korea, Republic of (South Korea)

Phone: +82-31-478-4185
Fax: +82-31-360-4277

Email: sales@logosbio.com

Company Profile

Website: www.logosbio.com

(1) Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse ModelAdvanced ScienceNovember 27, 2025Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, et al.incubation, the sample was placed in a vacuum at 37 °C for 3 h to initiate polymerization using the X‐CLARITY polymerization system (Logos Biosystems). The sample was wiped using a paper towel to remove excess hydrogel solution. The

(2) A neuronal architecture underlying autonomic dysreflexiaNatureSeptember 17, 2025Jan Elaine Soriano, Remi Hudelle, Lois Mahe, Matthieu Gautier, Alan Yue Yang Teo, Michael A. Skinnider, Achilleas Laskaratos, Steven Ceto, Claudia Kathe, Thomas Hutson, et al.Biosystems) for 24 h at 4 °C with gentle shaking12,55,60. Samples were degassed and polymerized using the X-CLARITY Polymerization System (Logos Biosystems), followed by washes in 0.001 M PBS for 5 min at room temperature. Samples were next

(3) Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse ModelbioRxivMay 31, 2025Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen James Perle, Shusaku Takahashi, Heather Brown-Harding, Linda Liang, Alex Lovely, Moustafa Algamal, et al.incubation, the sample was placed in a vacuum at 37°C for 3 hours to initiate polymerization using the X-CLARITY polymerization system (Logos Biosystems). The sample was wiped using a paper towel to remove excess hydrogel solution. The

(4) Plasma S100β is a predictor for pathology and cognitive decline in Alzheimer's diseaseFluids and barriers of the CNSJanuary 9, 2025Nehra G, Maloney BJ, Smith RR, Chumboatong W, Abner EL, Nelson PT, Bauer B, Hartz AMS.Biosystems, Annandale, VA, USA). After overnight incubation, sections were placed in the X-CLARITY™ system (C20001, Logos Biosystems, Annandale, VA, USA) for polymerization (3 h, − 90 kPa, 37 °C). Polymerized brain

(5) Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer’s pathologyCell ReportsAugust 27, 2024Theodore J. Zwang, Eric del del Sastre, Nina Wolf, Nancy Ruiz-Uribe, Benjamin Woost, Zachary Hoglund, Zhanyun Fan, Joshua Bailey, Lois Nfor, Luc Buée, et al.after adding the VA-044 until ready for the next step. After incubation, the tissue was placed in an X-CLARITY polymerization system (Logos Biosystems, South Korea) at 37°C for 3 h. Tissue was then rinsed with 50mL PBS for at least 3

(6) A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrainDevelopmental cellAugust 19, 2024Butts JC, Wu SR, Durham MA, Dhindsa RS, Revelli JP, Ljungberg MC, Saulnier O, McLaren ME, Taylor MD, Zoghbi HY.24 hours at 4°C and then polymerized for three hours at 37°C under a vacuum of −90kPa with the Logos X-CLARITY™ Polymerization System. The embryos were washed five times with 1X PBS for 30 minutes each with the last wash occurring overnight

(7) Advanced Immunolabeling Method for Optical Volumetric Imaging Reveals Dystrophic Neurites of Dopaminergic Neurons in Alzheimer’s Disease Mouse BrainMolecular NeurobiologyJuly 1, 2024Soonbong Baek, Jaemyung Jang, Hyun Jin Jung, Hyeyoung Lee, Youngshik Choeh with rocking. Tissues were transferred to sterile 1× PBS in a 6-well plate and polymerized in an X-CLARITY polymerization system (Logos Biosystems, cat. no. C30001) at 37 °C and 90 kPa for 3 h. After hydrogel polymerization, the

(8) Pre-hypertrophic chondrogenic enhancer landscape of limb and axial skeleton developmentNature CommunicationsJune 6, 2024Fabrice Darbellay, Anna Ramisch, Lucille Lopez-Delisle, Michael Kosicki, Antonella Rauseo, Zahra Jouini, Axel Visel, Guillaume Andreyhydrogel solution into the tissue. Polymerization of solution was carried in a Logos Polymerization (C20001, Logos Biosystem) system at 37 °C for 3 h. After two washes of 30’ in PBS, samples were immersed in

(9) Revealing the MRI‐Contrast in Optically Cleared BrainsAdvanced ScienceJune 1, 2024Shimrit Oz, Galit Saar, Shunit Olszakier, Ronit Heinrich, Mykhail O. Kompanets, Shai BerlinLogos Biosystems) and a subsequent hydrogel polymerization step was performed at 37 °C for 3 h at −90 kPa (cat #: C20001, Logos Biosystems). Polymerized brains were then actively cleared in electrophoretic tissue‐ clearing

(10) Comparative Anatomy of the Dentate Mossy Cells in Nonhuman Primates: Their Spatial Distributions and Axonal Projections Compared With Mouse Mossy CellseNeuroApril 30, 2024Minseok Jeong, Jinyoung Won, Kyung Seob Lim, Chang-Yeop Jeon, Youngshik Choe, Jin-Hyeok Jang, Chang Man Ha, Jong Hyuk Yoon, Yongjeon Lee, Yong-Seok Oh29:1) and 0.1% Azo-initiator (VA-044, Wako) overnight, followed by polymerization for 3 h at 37°C (X-Clarity polymerization system, Logos Biosystems). Polymerized tissues were cleared in an X-Clarity tissue clearing system II (Logos Biosystems

(11) Cholinergic Basal Forebrain Connectivity to the Basolateral Amygdala Modulates Food IntakeeNeuroFebruary 21, 2024Joshua Ortiz-Guzman, Jessica L. Swanson, Evelyne K. Tantry, Mikhail Kochukov, Kevin Ung, Angela P. Addison, Snigdha Srivastava, Benjamin D. Belfort, Emily Ji, Sean W. Dooling, et al.4°C. Next, the brains were transferred to a Logos Biosystems X-CLARITY Polymerization System (catalog #C20001) for tissue–hydrogel polymerization (settings: 37°C temperature, −90 kPa pressure, 3 h timer). After

(12) Biochemically functionalized probes for cell-type–specific targeting and recording in the brainScience AdvancesDecember 1, 2023Anqi Zhang, Theodore J. Zwang, Charles M. Lieberwere placed in freshly made acrylamide/VA-044 solution immediately before placing the brain slices in X-CLARITY polymerization system (Logos Biosystems) for 3 hours at 37°C. After polymerization, any remaining gel from the tissue surface

(13) Datasets assessing lipid-content in optically cleared brainsData in BriefNovember 30, 2023Shimrit Oz, Galit Saar, Shunit Olszakier, Ronit Heinrich, Mykhail O. Kompanets, Shai Berlina subsequent hydrogel polymerization step was performed at 37 °C for three hours at -90 kPa (cat #: C20001, Logos Biosystems). Polymerized brains were then actively cleared in electrophoretic tissue clearing

(14) Lymph Node Follicle‐Targeting STING Agonist Nanoshells Enable Single‐Shot M2e Vaccination for Broad and Durable Influenza ProtectionAdvanced ScienceJune 1, 2023Hsiao‐Han Tsai, Ping‐Han Huang, Leon CW Lin, Bing‐Yu Yao, Wan‐Ting Liao, Chen‐Hsueh Pai, Yu‐Han Liu, Hui‐Wen Chen, Che‐Ming J. HuHydrogel Solution (Logos Biosystems) at a 1:100 ratio at 4 °C for 24 h. Following polymerization with the X‐CLARITY Polymerization System, the hydrogel‐embedded tissue was placed into Electrophoretic Tissue Clearing Solution for passive tissue

(15) Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissueeLifeJanuary 19, 2023Zwang TJ, Bennett RE, Lysandrou M, Woost B, Zhang A, Lieber CM, Richardson DS, Hyman BT.day, the tissue was left in solution and placed in vacuum at 37°C for 3 hr. After polymerization with X-CLARITY polymerization system (Logos Biosystems, South Korea), the slices were rinsed with 50 ml PBS three times over 3 hr. Each slice

(16) Spatial characterization of tangle-bearing neurons and ghost tangles in the human inferior temporal gyrus with three-dimensional imagingBrain communicationsJanuary 1, 2023Zwang TJ, Woost B, Bailey J, Hoglund Z, Richardson DS, Bennett RE, Hyman BT.the tissue was left in solution and placed in vacuum at 37°C for 3 hours. After polymerization with X-CLARITY polymerization system (Logos Biosystems, South Korea), the slices were rinsed with 50 ml PBS three times over 3 hours. Each

(17) The autocrine loop of ALK receptor and ALKAL2 ligand is an actionable target in consensus molecular subtype 1 colon cancerJournal of Experimental & Clinical Cancer ResearchDecember 1, 2022Martina Mazzeschi et al.Gyunggi-Do, South Korea) according to manufacturer’s instructions. Samples were polymerized with the X- Clarity™ Polymerization System (Logos Biosystems) for 3 h with a vacuum of 90 kPa and a temperature of 37 °C. After polymerization,

(18) Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonadScience advancesMay 27, 2022Mayère C, Regard V, Perea-Gomez A, Bunce C, Neirijnck Y, Djari C, Bellido-Carreras N, Sararols P, Reeves R, Greenaway S, et al.solution into the tissue. Polymerization of solution was carried out in a Logos Polymerization system (C20001, Logos Biosystems) at 37°C for 3 hours. After two washes of 30 min in PBS, samples were immersed in

(19) Quantitative 3D analysis and visualization of cardiac fibrosis by microcomputed tomographySTAR ProtocolsMarch 1, 2022Vaibhao Janbandhu, Ella M.M.A. Martin, Gavin Chapman, Sally L. Dunwoodie, Richard P. HarveyScientific,http://www.fei.com/software/amira-3d-for-life-sciences/ RRID:SCR_007353 ,, Other,Other,Other ,, X-CLARITY Polymerization System,Logos Biosystems,Cat# C20001 SkyScan 1272,Bruker Corporation,Cat# SkyScan1272 Orthodontic tray wax,Kerr-Dental,Cat# 09246 500

(20) Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarctionCell stem cellFebruary 3, 2022Janbandhu V, Tallapragada V, Patrick R, Li Y, Abeygunawardena D, Humphreys DT, Martin EMMA, Ward AO, Contreras O, Farbehi N, et al.0.25% VA044, 0.05% Saponin) for 3 days at 4°C. The hearts were then polymerized in hydrogel using the X-Clarity Polymerization System (Logos Biosystems) (–90 kPa, 37°C, 3 hr 10 min). Hydrogel was then removed from the hearts, which were

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