FTY720 Phosphate from Cayman Chemical

Product Specs
ItemFTY720 Phosphate
CompanyCayman Chemical
Price $818.00Supplier Page View Company Product Page
Catalog Number10008639
Research AreaAdaptive Immunity, Autoimmunity, Glycerophospholipids, Immunology & Inflammation, Immunosuppressants, Innate Immunity, Lipid Biochemistry, Lipid Transport, Multiple Sclerosis, Neurodegenerative Disorders, Neuroscience, Phospholipases, Sphingolipids
FormatA crystalline solid
Molecular Weight387.5
Purity≥98%
Storage-20
FormulaC19H34NO5P
OriginUSA
TypeInhibitors
Quantity10 mg

Specifications/Features

Ki, IC, EC, or working concentration: IC50: 0.2-6 nM

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Investigating FTY720-NF immunomodulation of key lipid, gene, and protein mediators to enhance oral tissue regenerationBiomaterials AdvancesOctober 1, 2026Afra I. Toma, Daniel C. Shah, Victoria R. Duke, Nathan F. Chiappa, Keerthi P. Chinniampalayam Sekar, Tim Cha, Archana Kamalakar, Levi B. Wood, Edward A. Botchwey, Nick J. Willett, et al.(1.5×105 cells/mL) were transferred to 6-well plates and conditioned with FTY720P (Cayman Chemicals #10008639) and/or Lipopolysaccharide (LPS) (Millipore Sigma L6529–1MG) as followed: no treatment, LPS-Only (0.5

(2) FTY720P-treated macrophages in PEG-4MAL hydrogels promote oral wound healingCytotherapyMarch 1, 2025Andre J. Burnham, Afra I. Toma, Daniel Shah, Tim Cha, Sundus Kaimari, Monica Behara, Keerthi Priya Chinniampalayam Sekar, Archana Kamalakar, Nick Willett, Edward Botchwey, et al.264.7 or M0-differentuated THP1 cells were pre-treated with select concentrations of FTY720P (Cayman, 10008639) for 1 hour at 37°C. Cell proliferation assays PEG-4MAL hydrogels were prepared as previously described.

(3) TRPM7’s Channel Activity Promotes the Pathogenesis of Abdominal Aortic AneurysmNature Cardiovascular ResearchFebruary 14, 2025Pengyu Zong, Cindy X. Li, Jianlin Feng, Zhichao Yue, Thushara Nethramangalath, Yangzhouyun Xie, Xin Qin, Mara Cicchetti, Yujun Cai, Evan Jellison, et al.(Cayman chemical, 10007965); NS8593 (hydrochloride) (Cayman chemical, 29774); FTY720 Phosphate (Cayman chemical, 10008639); EGTA (Cayman chemical, 11706); TPEN (Cayman chemical, 13340); NFAT Inhibitor (Cayman chemical, 13855);

(4) FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemiaCell death & diseaseNovember 7, 2019Young MM, Bui V, Chen C, Wang HG.#LT07-318). Chemicals and reagents FTY720 (dissolved in DMSO; #10006292), FTY720-phosphate (dissolved in DMSO; #10008639), NBD-FTY720 (dissolved in DMSO; #16841), calyculin A (#19246) and necrosulfonamide (#20844) were purchased

(5) Fingolimod Alters Tissue Distribution and Cytokine Production of Human and Murine Innate Lymphoid CellsFrontiers in immunologyJanuary 1, 2019Eken A, Yetkin MF, Vural A, Okus FZ, Erdem S, Azizoglu ZB, Haliloglu Y, Cakir M, Turkoglu EM, Kilic O, et al.intraperitoneally for 15-to 30 days. As control, PBS was given. SEW2871 (10006440 256414-75-2) and FTY720-P (10008639) were purchased from Cayman. For gavage feeding, Gilenya (Novartis) 0.5 mg tablets were reconstituted

(6) The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cellsScientific reportsNovember 16, 2016Rahman MM, Prünte L, Lebender LF, Patel BS, Gelissen I, Hansbro PM, Morris JC, Clark AR, Verrills NM, Ammit AJ.anti-inflammatories in chronic respiratory diseases. Methods Chemicals FTY720 (C/N 10006292) and FTY720-P (C/N 10008639) was purchased from the Cayman Chemical Company (Ann Arbor, MI). TNF was from R&D Systems (Minneapolis,

(7) p38 mitogen-activated protein kinase regulates type-Ivstype-II phenotyping of human vascular endothelial cellsWorld Journal of Translational MedicineJanuary 1, 2015Masako NakaharaCalbiochem Co.,) was dissolved by DMSO at the concentration of 50 mmol/L stock. FTY720 Phosphate (#10008639, Cayman Chemical Co.,) was dissolved by chloroform at the concentration of 0.5 mg/ ml as a stock. All

(8) Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal AdenocarcinomaCell reportsJanuary 1, 0001"Burrack AL, Spartz EJ, Raynor JF, Wang I, Olson M, Stromnes IM."H155–78),Biolegend,141008 "Chemicals, Peptides, and Recombinant Proteins",, FTY720,Cayman Chemical,Cat No. 10008639 D-Luciferin,Gold Bio,LUCK-100 Poly I:C,Sigma-Aldrich,P1530 Recombinant mouse IFNγ,R&D systems,485-MI-100 Click

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