Description
An NSAID and active metabolite of sulfasalazine, balsalazide, and olsalazine; selectively inhibits COX-2 over COX-1 in isolated human whole blood (IC50s = 61 and 410 µM, respectively); inhibits hemoglobin- and hydrogen peroxide-induced lipid peroxidation in a cell-free assay (IC50 = 50 µM); inhibits the synthesis of LTB4 in isolated human mucosal cells at 100 µM