Description
An L-type calcium channel blocker; reduces amplitude of spontaneous contractions in isolated rabbit ileum at 1 µM; reduces TGF-β-induced calcium oscillations in human fibroblasts at 1 µM; prevents impairment of lung function in a mouse model of bleomycin-induced pulmonary fibrosis at 10 mg/kg per day; reduces increases in mean arterial blood pressure induced by angiotensin II in spontaneously hypertensive rats at 10 µg/kg