(-)-Bicuculline methiodide from Tocris Bioscience, a Bio-Techne Brand

Product Specs
Item(-)-Bicuculline methiodide
CompanyTocris Bioscience, a Bio-Techne Brand
Price $122.00Supplier Page View Company Product Page
Catalog Number2503/10
Purity98%
Molecular Weight509.3
Molecule Name[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
FormulaC21H20INO6
StorageStore at RT
Quantity10 mg (also 50 mg)

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

Add to Compare List

Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Humid heat environment causes anxiety-like disorder via impairing gut microbiota and bile acid metabolism in miceNature CommunicationsJuly 7, 2024Huandi Weng, Li Deng, Tianyuan Wang, Huachong Xu, Jialin Wu, Qinji Zhou, Lingtai Yu, Boli Chen, Li’an Huang, Yibo Qu, et al.−70 mV. Spontaneous excitatory postsynaptic currents (sEPSCs) were recorded using 20 μM bicuculline (2503/10, Tocris) and a K+-based peptide solution at the electrodes. Spontaneous inhibitory postsynaptic currents

(2) Protocol for detecting plastic changes in defined neuronal populations in neuropathic miceSTAR protocolsSeptember 17, 2021Zhang Z, Zamponi GW.2313/50 TTX,Alomone Labs,Cat #: T-550 4-AP,Sigma-Aldrich,Cat #: A-0152 (-)-Bicuculine methiodide,Tocris,Cat #: 2503/10 DNQX disodium salt,Tocris,Cat #: 2312/10 DL-AP5,Tocris,Cat #: 3693/10 Mineral oil (low molecular

(3) Proline-rich transmembrane protein 2 (PRRT2) regulates the actin cytoskeleton during synaptogenesisCell death & diseaseOctober 14, 2020Savino E, Cervigni RI, Povolo M, Stefanetti A, Ferrante D, Valente P, Corradi A, Benfenati F, Guarnieri FC, Valtorta F.D-(-)-2-Amino-5-phosphonopentanoic acid (D-AP5; 50 μM, Tocris #0106), Bicuculline methiodide (30 μm, Tocris #2503/10) and CGP 55845 hydrochloride (10 μM, Tocris #1248/10), to block NMDA, GABAA and GABAB receptors, respectively.

(4) Ketamine metabolite (2R,6R)-hydroxynorketamine enhances aggression via periaqueductal gray glutamatergic transmissionNeuropharmacologyOctober 1, 2019Ye L, Ko CY, Huang Y, Zheng C, Zheng Y, Chou D.

(5) Wilm's tumor 1 promotes memory flexibilityNature communicationsAugust 21, 2019Mariottini C, Munari L, Gunzel E, Seco JM, Tzavaras N, Hansen J, Stern SA, Gao V, Aleyasin H, Sharma A, et al.

(6) NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic ContentCell reportsJuly 9, 2019Chiu AM, Wang J, Fiske MP, Hubalkova P, Barse L, Gray JA, Sanz-Clemente A.

(7) (2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal grayNeuropharmacologySeptember 1, 2018Chou D, Peng HY, Lin TB, Lai CY, Hsieh MC, Wen YC, Lee AS, Wang HH, Yang PS, Chen GD, et al.

(8) Neuronal Activity and Intracellular Calcium Levels Regulate Intracellular Transport of Newly Synthesized AMPARCell reportsJuly 24, 2018Hangen E, Cordelières FP, Petersen JD, Choquet D, Coussen F.

(9) Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule CellsNeuronJuly 1, 2018Subhrajit Bhattacharya, Alpa Khatri, Sharon A. Swanger, John O. DiRaddo, Feng Yi, Kasper B. Hansen, Hongjie Yuan, Stephen F. Trayneliscontained 1 μM TTX (Tocris, Bristol, UK, Cat. No. 1078/1), 20 μM bicuculline (Tocris, Bristol, UK, Cat. No. 2503/10), and 10 μM CNQX purchase from Tocris, Bristol, UK, Cat. No. 1045/1 (Lee et al., 2007). Voltage clamp

(10) Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain CircuitsNeuronApril 4, 2018Wang D, Tawfik VL, Corder G, Low SA, François A, Basbaum AI, Scherrer G.

(11) A versatile optical tool for studying synaptic GABA_A receptor traffickingJournal of cell scienceNovember 15, 2017Lorenz-Guertin JM, Wilcox MR, Zhang M, Larsen MB, Pilli J, Schmidt BF, Bruchez MP, Johnson JW, Waggoner AS, Watkins SC, et al.

(12) Src homology 2 domain-containing phosphotyrosine phosphatase 2 (Shp2) controls surface GluA1 protein in synaptic homeostasisThe Journal of biological chemistrySeptember 15, 2017Zhang B, Lu W.

(13) Differential Desensitization Observed at Multiple Effectors of Somatic μ-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron ActivityThe Journal of neuroscience : the official journal of the Society for NeuroscienceSeptember 6, 2017Fox PD, Hentges ST.

(14) HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salienceNature communicationsAugust 4, 2017Raza SA, Albrecht A, Çalışkan G, Müller B, Demiray YE, Ludewig S, Meis S, Faber N, Hartig R, Schraven B, et al.

(15) Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate GyrusNeuronAugust 2, 2017Medrihan L, Sagi Y, Inde Z, Krupa O, Daniels C, Peyrache A, Greengard P.

(16) Amygdalar Endothelin-1 Regulates Pyramidal Neuron Excitability and Affects AnxietyScientific reportsMay 24, 2017Chen M, Yan HH, Shu S, Pei L, Zang LK, Fu Y, Wang ZF, Wan Q, Bi LL.

(17) A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and EnkephalinsNeuronFebruary 22, 2017François A, Low SA, Sypek EI, Christensen AJ, Sotoudeh C, Beier KT, Ramakrishnan C, Ritola KD, Sharif-Naeini R, Deisseroth K, et al.

(18) Salicylate-Induced Suppression of Electrically Driven Activity in Brain Slices from the Auditory Cortex of Aging MiceFrontiers in aging neuroscienceJanuary 1, 2017Namikawa M, Sano A, Tateno T.

(19) Increased Activity of Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Regulates Activity-dependent AMPA Receptor TraffickingThe Journal of biological chemistrySeptember 2, 2016Zhang B, Du YL, Lu W, Yan XY, Yang Q, Yang W, Luo JH.

(20) Diminished KCC2 confounds synapse specificity of LTP during senescenceNature neuroscienceSeptember 1, 2016Ferando I, Faas GC, Mody I.

Be the First to Write a Review!