GW 4064 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemGW 4064
CompanyTocris Bioscience, a Bio-Techne Brand
Price $216.00Supplier Page View Company Product Page
Catalog Number2473/10
Quantity10 mg (also 50 mg)
Purity97%
Molecular Weight542.84
Molecule Name3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic acid
FormulaC28H22Cl3NO4
StorageStore at +4°C

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXRInternational journal of molecular medicineMay 1, 2019Dong B, Singh AB, Guo GL, Young M, Liu J.

(2) Activation of FXR promotes intestinal metaplasia of gastric cells via SHP-dependent upregulation of the expression of CDX2Oncology lettersMay 1, 2018Zhou H, Ni Z, Li T, Su L, Zhang L, Liu N, Shi Y.

(3) Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasisNature communicationsApril 11, 2018El Kasmi KC, Vue PM, Anderson AL, Devereaux MW, Ghosh S, Balasubramaniyan N, Fillon SA, Dahrenmoeller C, Allawzi A, Woods C, et al.

(4) Activation of FXR pathway does not alter glial cell functionJournal of neuroinflammationMarch 28, 2017Albrecht S, Fleck AK, Kirchberg I, Hucke S, Liebmann M, Klotz L, Kuhlmann T.

(5) The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulationScientific reportsNovember 21, 2016Kim H.

(6) Activated FXR Inhibits Leptin Signaling and Counteracts Tumor-promoting Activities of Cancer-Associated Fibroblasts in Breast MalignancyScientific reportsFebruary 22, 2016Giordano C, Barone I, Vircillo V, Panza S, Malivindi R, Gelsomino L, Pellegrino M, Rago V, Mauro L, Lanzino M, et al.

(7) Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasisNature communicationsFebruary 18, 2016Gomez-Ospina N, Potter CJ, Xiao R, Manickam K, Kim MS, Kim KH, Shneider BL, Picarsic JL, Jacobson TA, Zhang J, et al.

(8) Hormesis in Cholestatic Liver Disease; Preconditioning with Low Bile Acid Concentrations Protects against Bile Acid-Induced ToxicityPloS oneJanuary 1, 2016Verhaag EM, Buist-Homan M, Koehorst M, Groen AK, Moshage H, Faber KN.

(9) Nutrient-sensing nuclear receptors coordinate autophagyNatureDecember 4, 2014Lee JM, Wagner M, Xiao R, Kim KH, Feng D, Lazar MA, Moore DD.

(10) GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cellsWorld journal of gastroenterologyNovember 14, 2014Xin XM, Zhong MX, Yang GL, Peng Y, Zhang YL, Zhu W.

(11) Cysteine sulfinic acid decarboxylase regulation: A role for farnesoid X receptor and small heterodimer partner in murine hepatic taurine metabolismHepatology research : the official journal of the Japan Society of HepatologyOctober 1, 2014Kerr TA, Matsumoto Y, Matsumoto H, Xie Y, Hirschberger LL, Stipanuk MH, Anakk S, Moore DD, Watanabe M, Kennedy S, et al.

(12) Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsteroneBiochimica et biophysica actaSeptember 1, 2014Yang L, Broderick D, Jiang Y, Hsu V, Maier CS.

(13) Regulation of human cytosolic sulfotransferases 1C2 and 1C3 by nuclear signaling pathways in LS180 colorectal adenocarcinoma cellsDrug metabolism and disposition: the biological fate of chemicalsMarch 1, 2014Rondini EA, Fang H, Runge-Morris M, Kocarek TA.

(14) Human FXR regulates SHP expression through direct binding to an LRH-1 binding site, independent of an IR-1 and LRH-1PloS oneJanuary 1, 2014Hoeke MO, Heegsma J, Hoekstra M, Moshage H, Faber KN.

(15) Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophagesJournal of leukocyte biologyDecember 1, 2013Haselow K, Bode JG, Wammers M, Ehlting C, Keitel V, Kleinebrecht L, Schupp AK, Häussinger D, Graf D.

(16) Positive regulation of osteogenesis by bile acid through FXRJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchOctober 1, 2013Cho SW, An JH, Park H, Yang JY, Choi HJ, Kim SW, Park YJ, Kim SY, Yim M, Baek WY, et al.

(17) Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discoveryBioorganic & medicinal chemistryJuly 15, 2013Yu DD, Lin W, Chen T, Forman BM.

(18) Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expressionMolecular endocrinology (Baltimore, Md.)May 1, 2012Liu N, Meng Z, Lou G, Zhou W, Wang X, Zhang Y, Zhang L, Liu X, Yen Y, Lai L, et al.

(19) Impact of bile acids on the growth of human cholangiocarcinoma via FXRJournal of hematology & oncologyOctober 12, 2011Dai J, Wang H, Shi Y, Dong Y, Zhang Y, Wang J.

(20) Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathwayProceedings of the National Academy of Sciences of the United States of AmericaJanuary 25, 2011Fu D, Wakabayashi Y, Lippincott-Schwartz J, Arias IM.

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GW 4064

GW 4064 from Tocris Bioscience, a Bio-Techne Brand

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Tocris Bioscience, a Bio-Techne Brand

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GW 4064 from Tocris Bioscience, a Bio-Techne Brand

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