IEM 1460 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemIEM 1460
CompanyTocris Bioscience, a Bio-Techne Brand
Price $172.00Supplier Page View Company Product Page
Catalog Number1636/10
Quantity10 mg (also 50 mg)
Purity98%
Molecular Weight454.33
Molecule NameN,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide
FormulaC19H37N2Br.HBr
StorageDesiccate at RT

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Ketamine’s rapid antidepressant effects are mediated by Ca2+-permeable AMPA receptorseLifeJune 26, 2023Anastasiya Zaytseva, Evelina Bouckova, McKennon J Wiles, Madison H Wustrau, Isabella G Schmidt, Hadassah Mendez-Vazquez, Latika Khatri, Seonil Kim(NASPM),Tocris Bioscience,Cat. #: 2766,20 μM "Chemical compound, drug",IEM-1460,Tocris Bioscience,Cat. #: 1636,10 mg/kg "Chemical compound, biotin",Sulfo-NHS-SS-biotin,Thermo Fisher Scientific,Cat. #: PI21331, "Chemical

(2) Ketamine’s rapid antidepressant effects are mediated by Ca2+-permeable AMPA receptorsElifeJune 26, 2023Anastasiya Zaytseva, Evelina Bouckova, McKennon J Wiles, Madison H Wustrau, Isabella G Schmidt, Hadassah Mendez-Vazquez, Latika Khatri, Seonil Kim(NASPM),Tocris Bioscience,Cat. #: 2766,20 μM "Chemical compound, drug",IEM-1460,Tocris Bioscience,Cat. #: 1636,10 mg/kg "Chemical compound, biotin",Sulfo-NHS-SS-biotin,Thermo Fisher Scientific,Cat. #: PI21331, "Chemical

(3) AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca²⁺-Permeable AMPA Receptors to Control LTPCell reportsOctober 23, 2018Purkey AM, Woolfrey KM, Crosby KC, Stich DG, Chick WS, Aoto J, Dell'Acqua ML.

(4) Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neuronseLifeAugust 1, 2017Suyama S, Ralevski A, Liu ZW, Dietrich MO, Yada T, Simonds SE, Cowley MA, Gao XB, Diano S, Horvath TL.

(5) Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the HippocampusThe Journal of neuroscience : the official journal of the Society for NeuroscienceJanuary 13, 2016Park P, Sanderson TM, Amici M, Choi SL, Bortolotto ZA, Zhuo M, Kaang BK, Collingridge GL.

(6) Inhibition of Spinal Ca(2+)-Permeable AMPA Receptors with Dicationic Compounds Alleviates Persistent Inflammatory Pain without Adverse EffectsFrontiers in cellular neuroscienceJanuary 1, 2016Kopach O, Krotov V, Goncharenko J, Voitenko N.

(7) Long-term upregulation of cortical glutamatergic AMPA receptors in a mouse model of chronic visceral painMolecular brainNovember 19, 2015Liu SB, Zhang MM, Cheng LF, Shi J, Lu JS, Zhuo M.

(8) Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortexScientific reportsSeptember 15, 2015Tang B, Luo D, Yang J, Xu XY, Zhu BL, Wang XF, Yan Z, Chen GJ.

(9) Heterogeneity in expression of functional ionotropic glutamate and GABA receptors in astrocytes across brain regions: insights from the thalamusPhilosophical transactions of the Royal Society of London. Series B, Biological sciencesOctober 19, 2014Höft S, Griemsmann S, Seifert G, Steinhäuser C.

(10) Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanismsThe Journal of pharmacology and experimental therapeuticsDecember 1, 2013Chen SR, Zhou HY, Byun HS, Pan HL.

(11) Acquisition of contextual discrimination involves the appearance of a RAS-GRF1/p38 mitogen-activated protein (MAP) kinase-mediated signaling pathway that promotes long term potentiation (LTP)The Journal of biological chemistryJuly 26, 2013Jin SX, Arai J, Tian X, Kumar-Singh R, Feig LA.

(12) Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cordNeuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyJuly 1, 2013Cabañero D, Baker A, Zhou S, Hargett GL, Irie T, Xia Y, Beaudry H, Gendron L, Melyan Z, Carlton SM, et al.

(13) Action potential-independent and pharmacologically unique vesicular serotonin release from dendritesThe Journal of neuroscience : the official journal of the Society for NeuroscienceNovember 7, 2012Colgan LA, Cavolo SL, Commons KG, Levitan ES.

(14) Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptorsThe Journal of neuroscience : the official journal of the Society for NeuroscienceJune 13, 2012Fortin DA, Srivastava T, Dwarakanath D, Pierre P, Nygaard S, Derkach VA, Soderling TR.

(15) Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal hornPainApril 1, 2011Kopach O, Kao SC, Petralia RS, Belan P, Tao YX, Voitenko N.

(16) Functional refinement in the projection from ventral cochlear nucleus to lateral superior olive precedes hearing onset in ratPloS oneJanuary 1, 2011Case DT, Zhao X, Gillespie DC.

(17) Transmission efficacy and plasticity in glutamatergic synapses formed by excitatory interneurons of the substantia gelatinosa in the rat spinal cordPloS oneNovember 30, 2009Santos SF, Luz LL, Szucs P, Lima D, Derkach VA, Safronov BV.

(18) Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spinesThe Journal of neuroscience : the official journal of the Society for NeuroscienceAugust 5, 2009Hildebrand ME, Isope P, Miyazaki T, Nakaya T, Garcia E, Feltz A, Schneider T, Hescheler J, Kano M, Sakimura K, et al.

(19) Recruitment of calcium-permeable AMPA receptors during synaptic potentiation is regulated by CaM-kinase IThe Journal of neuroscience : the official journal of the Society for NeuroscienceJune 4, 2008Guire ES, Oh MC, Soderling TR, Derkach VA.