Paxilline from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemPaxilline
CompanyTocris Bioscience, a Bio-Techne Brand
Price $407.00Supplier Page View Company Product Page
Catalog Number2006/10
Quantity10 mg
Purity98%
Molecular Weight435.56
Molecule Name(2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one
FormulaC27H33NO4
StorageStore at -20°C

Specifications/Features

Sizes Available: 10 mg

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K⁺ Channel THIK-1NeuronJanuary 17, 2018Madry C, Kyrargyri V, Arancibia-Cárcamo IL, Jolivet R, Kohsaka S, Bryan RM, Attwell D.

(2) Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neuronsPloS oneJanuary 1, 2018Fernández-Fernández D, Cadaveira-Mosquera A, Rueda-Ruzafa L, Herrera-Pérez S, Veale EL, Reboreda A, Mathie A, Lamas JA.

(3) Activation of human B cells negatively regulates TGF-β1 productionJournal of NeuroinflammationDecember 1, 2017Nicolas Molnarfi, Kristbjörg Bjarnadóttir, Mahdia Benkhoucha, Catherine Juillard, Patrice H. Laliveassays, B cells (4 × 105) were cultured in 250 μL of serum-free complete X-Vivo 15 medium with CpG-B 2006 (10 μg/mL) + anti-Ig (10 μg/mL) in 96-well flat-bottom plates. At 24 h, cell-free supernatants were analyzed

(4) Ethanol-Sensitive Pacemaker Neurons in the Mouse External Globus PallidusNeuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyApril 1, 2017Abrahao KP, Chancey JH, Chan CS, Lovinger DM.

(5) BKCa channel regulates calcium oscillations induced by alpha-2-macroglobulin in human myometrial smooth muscle cellsProceedings of the National Academy of Sciences of the United States of AmericaApril 19, 2016Wakle-Prabagaran M, Lorca RA, Ma X, Stamnes SJ, Amazu C, Hsiao JJ, Karch CM, Hyrc KL, Wright ME, England SK.

(6) BK channel inactivation gates daytime excitability in the circadian clockNature communicationsMarch 4, 2016Whitt JP, Montgomery JR, Meredith AL.

(7) Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and ExpressionThe Journal of neuroscience : the official journal of the Society for NeuroscienceSeptember 23, 2015Simkin D, Hattori S, Ybarra N, Musial TF, Buss EW, Richter H, Oh MM, Nicholson DA, Disterhoft JF.

(8) Astrocyte contributions to flow/pressure-evoked parenchymal arteriole vasoconstrictionThe Journal of neuroscience : the official journal of the Society for NeuroscienceMay 27, 2015Kim KJ, Iddings JA, Stern JE, Blanco VM, Croom D, Kirov SA, Filosa JA.

(9) BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje CellsThe Journal of neuroscience : the official journal of the Society for NeuroscienceMay 6, 2015Hirono M, Ogawa Y, Misono K, Zollinger DR, Trimmer JS, Rasband MN, Misonou H.

(10) Immunological Analyses of Whole Blood via “Microfluidic Drifting” Based Flow Cytometric ChipAnnals of Biomedical EngineeringNovember 1, 2014Ahmad Ahsan Nawaz, Ruth Helmus Nissly, Peng Li, Yuchao Chen, Feng Guo, Sixing Li, Yasir M. Shariff, Arooj Nawaz Qureshi, Lin Wang, Tony Jun Huangtwodimensional ﬂuidic lens for integration into microﬂuidic ﬂow cytometers. Appl. Phys. Lett. 89:061106, 2006. 10 Godin, J., and Y.-H. Lo. Two-parameter angular light scatter collection for microﬂuidic ﬂow cytometry

(11) BK channels regulate sinoatrial node firing rate and cardiac pacing in vivoAmerican journal of physiology. Heart and circulatory physiologyNovember 1, 2014Lai MH, Wu Y, Gao Z, Anderson ME, Dalziel JE, Meredith AL.

(12) Prostaglandin E2 excitatory effects on guinea pig urinary bladder smooth muscle: a novel regulatory mechanism mediated by large-conductance voltage- and Ca2+-activated K+ channelsEuropean journal of pharmacologySeptember 5, 2014Parajuli SP, Provence A, Petkov GV.

(13) Caveolin-1 facilitates the direct coupling between large conductance Ca2+-activated K+ (BKCa) and Cav1.2 Ca2+ channels and their clustering to regulate membrane excitability in vascular myocytesThe Journal of biological chemistryDecember 20, 2013Suzuki Y, Yamamura H, Ohya S, Imaizumi Y.

(14) Reduced vascular smooth muscle BK channel current underlies heart failure-induced vasoconstriction in miceFASEB journal : official publication of the Federation of American Societies for Experimental BiologyMay 1, 2013Wan E, Kushner JS, Zakharov S, Nui XW, Chudasama N, Kelly C, Waase M, Doshi D, Liu G, Iwata S, et al.

(15) Mis-expression of the BK K(+) channel disrupts suprachiasmatic nucleus circuit rhythmicity and alters clock-controlled behaviorAmerican journal of physiology. Cell physiologyFebruary 15, 2013Montgomery JR, Whitt JP, Wright BN, Lai MH, Meredith AL.

(16) Improvement and Simulation of an Autonomous Time Synchronization Algorithm for a Layered Satellite ConstellationMathematical Problems in EngineeringJanuary 1, 2013Feijiang Huang, Xiaochun Lu, Guangcan Liu, Liping Sun, Wang Sheng, Yingde Wang“Recent progress in atomic time and frequency,” World Sci-Tech R and D, vol. 28, no. 3, pp. 63–69, 2006. [10] P. Shuai and G. J. Qu, “Time synchronization techniques of the autonomous navigation of navigation

(17) Properties of BK-type Ca(+) (+)-dependent K(+) channel currents in medial prefrontal cortex pyramidal neurons in rats of different agesFrontiers in cellular neuroscienceJanuary 1, 2013Książek A, Ladno W, Szulczyk B, Grzelka K, Szulczyk P.

(18) The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig tracheaAmerican journal of physiology. Lung cellular and molecular physiologyDecember 1, 2012Pulkkinen V, Manson ML, Säfholm J, Adner M, Dahlén SE.

(19) Function and expression of ryanodine receptors and inositol 1,4,5-trisphosphate receptors in smooth muscle cells of murine feed arteries and arteriolesThe Journal of physiologyApril 15, 2012Westcott EB, Goodwin EL, Segal SS, Jackson WF.

(20) Redox sensitive calcium stores underlie enhanced after hyperpolarization of aged neurons: role for ryanodine receptor mediated calcium signalingJournal of neurophysiologyNovember 1, 2010Bodhinathan K, Kumar A, Foster TC.