ICI 182,780 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemICI 182,780
CompanyTocris Bioscience, a Bio-Techne Brand
Price $142.00Supplier Page View Company Product Page
Catalog Number1047/1
Quantity1 mg (also 10 mg, 50 mg)
Purity98%
Molecular Weight606.77
Molecule Name7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol
FormulaC32H47F5O3S
StorageStore at RT

Specifications/Features

Sizes Available: 1 mg (also 10 mg, 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Estrogen Induced Regulation of Mucosal‐Associated Invariant T Cells in AsthmaJournal of Immunology ResearchMarch 20, 2026Shubhanshi Trivedi, Samuel E. Aamodt, Thomas P. Huecksteadt, Elizabeth J. Myers, Grace Helen McGee, Jackson G. Cacioppo, Jeffrey Aubé, Robert Paine, Daniel T. Leung, Kristi J. Warrencat# 4759, Bio‐techne, R&D Systems Inc., MN) or 200 nM ICI 182,780 (ER antagonist/GPER‐1 agonist, cat# 1047/1, Bio‐techne, R&D Systems Inc., MN) for 20 min in a 37°C incubator prior to addition of estrogen (cat#50‐28‐2,

(2) Beta-cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthoodJCI InsightNovember 8, 2022Anne-Laure Castell, Clara Goubault, MÃ©lanie Ethier, Grace Fergusson, Caroline Tremblay, Marie Baltz, DorothÃ©e Dal Soglio, Julien Ghislain, Vincent Poitoutantagonist SB204741 and the estrogen receptor antagonist ICI 182,780 were from Tocris (catalogs 1372/10 and 1047/1, respectively). Recombinant rat GH protein (rGH) was from Abcam (catalog ab68388). BrdU, the androgen

(3) Sensitive image-based chromatin binding assays using inducible ERα to rapidly characterize estrogenic chemicals and mixturesiScienceOctober 21, 2022Adam T. Szafran, Maureen G. Mancini, Fabio Stossi, Michael A. Mancini(4HT),Sigma,H6278 Bazedoxifene,Sigma,PZ0018 AZD9496,Sellek Chemicals,S8372 H3B-5942,Sellek Chemicals,HY-112611 "ICI 182,790",Tocris Bioscience,1047/1 ZK 164015,Tocris Bioscience,2183/10 Toremifene citrate,Toronto Research Chemicals,T547500 EPA 45

(4) Chronic cadmium exposure decreases the dependency of MCF7 breast cancer cells on ERαScientific reportsAugust 20, 2019Bloomfield M, Louie MC.

(5) F-Spondin Is the Signal by Which 2-Methoxyestradiol Induces Apoptosis in the Endometrial Cancer Cell Line IshikawaInternational journal of molecular sciencesAugust 7, 2019Rincón-Rodriguez R, Mena D, Mena J, Díaz-Saldivar P, Guajardo-Correa E, Godoy-Guzman C, Cardenas H, Orihuela PA.

(6) Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancerMolecular oncologyAugust 1, 2019Hosford SR, Shee K, Wells JD, Traphagen NA, Fields JL, Hampsch RA, Kettenbach AN, Demidenko E, Miller TW.

(7) Data on UPLC/MS method validation for the biodegradation of pharmaceuticals and intermediates by a fungal consortium and on T47DK-Bluc reporter gene assay to assess the reduction of their estrogenic activityData in briefAugust 1, 2019Kasonga TK, Coetzee MAA, Van Zijl C, Benteke Momba MN.

(8) Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampusMolecular medicine reportsJuly 1, 2019Liu L, Yan J, Ge F, Xu X, Lu J, Shi H, Li S, Zhao Y, Zhang C.was dissolved in sesame oil. The non‑selective estrogen receptor (ER) inhibitor ICI182780 (cat. no. 1047/1; Tocris Bioscience) was first dissolved in dimethyl sulfoxide (10 mM; cat. no. d103273; Shanghai Aladdin

(9) Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptorOncogeneApril 1, 2019Cortes E, Lachowski D, Rice A, Thorpe SD, Robinson B, Yeldag G, Lee DA, Ghemtio L, Rombouts K, Del Río Hernández AE.

(10) Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast CancerFrontiers in oncologyJanuary 1, 2019Demas DM, Demo S, Fallah Y, Clarke R, Nephew KP, Althouse S, Sandusky G, He W, Shajahan-Haq AN.

(11) Tamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survivalEMBO reportsJanuary 1, 2019Cortes E, Lachowski D, Robinson B, Sarper M, Teppo JS, Thorpe SD, Lieberthal TJ, Iwamoto K, Lee DA, Okada-Hatakeyama M, et al.

(12) GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironmentEMBO reportsJanuary 1, 2019Cortes E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe SD, Lee DA, Del Río Hernández AE.

(13) The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cellseLifeNovember 29, 2018Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Han R, et al.drug 4-hydroxyt amoxifen Tocris 3412 Chemical compound, drug ICI 182–780 (fulvestrant) Tocris 1047/1 Chemical compound, drug Raloxifene SigmaAldrich R1402 Chemical compound, drug Estradiol SigmaAldrich E8875 RRID Breast cancer

(14) Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancerBreast cancer research : BCRSeptember 4, 2018Du T, Sikora MJ, Levine KM, Tasdemir N, Riggins RB, Wendell SG, Van Houten B, Oesterreich S.

(15) A transcriptomics model of estrogen action in the ovine fetal hypothalamus: evidence for estrogenic effects of ICI 182,780Physiological reportsSeptember 1, 2018Rabaglino MB, Keller-Wood M, Wood CE.

(16) Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoirProceedings of the National Academy of Sciences of the United States of AmericaAugust 14, 2018Das B, Dobrowolski C, Luttge B, Valadkhan S, Chomont N, Johnston R, Bacchetti P, Hoh R, Gandhi M, Deeks SG, et al.

(17) Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistanceOncotargetJune 19, 2018Kaymak A, Sayols S, Papadopoulou T, Richly H.

(18) The impact of 27-hydroxycholesterol on endometrial cancer proliferationEndocrine-related cancerApril 1, 2018Gibson DA, Collins F, Cousins FL, Esnal Zufiaurre A, Saunders PTK.

(19) 17β-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct OutcomesJournal of the Endocrine SocietyMarch 1, 2018Jallow F, Brockman JL, Helzer KT, Rugowski DE, Goffin V, Alarid ET, Schuler LA.

(20) Brain Aromatase Modulates Serotonergic Neuron by Regulating Serotonin Levels in Zebrafish Embryos and LarvaeFrontiers in endocrinologyJanuary 1, 2018Ulhaq ZS, Kishida M.

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ICI 182,780

ICI 182,780 from Tocris Bioscience, a Bio-Techne Brand

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Tocris Bioscience, a Bio-Techne Brand

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ICI 182,780 from Tocris Bioscience, a Bio-Techne Brand

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