Erlotinib from Cayman Chemical

Product Specs
ItemErlotinib
CompanyCayman Chemical
Price $469.00Supplier Page View Company Product Page
Catalog Number10483
Quantity5 g
Research AreaApoptosis, Cancer, Cell Death, Cell Signaling, Growth Factor Receptor Signaling
FormatA crystalline solid
Molecular Weight393.4
Purity≥98%
Storage-20
FormulaC22H23N3O4
OriginCHN
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) ECM (collagen) mediated signaling drives the emergence of androgen independence in prostate cancer cellsBiochem Biophys RepApril 18, 2026Apoorva Abikar, Prathibha Ranganathan,Cayman Chemicals,14924,FAKi,10 nM Flutamide,Cayman Chemicals,20359,Flut,5 μM Erlotinib,Cayman Chemicals,10483,Erlo,5 μM EGF,Thermofischer scientific,P01133,EGF,10 nM Docetaxel,Cayman Chemicals,11637,Doce,0.1-10

(2) Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically diverse Caenorhabditis nematodesElifeDecember 23, 2025Stephen A Banse, Christine A Sedore, Anna Coleman-Hulbert, Erik Johnson, Brian Onken, David Hall, Erik Segerdell, E Grace Jackson, Yuhua Song, Haley C Osman, et al.arecoline (Cayman 13662), everolimus (Cayman 11597), temsirolimus (Cayman 11590), erlotinib (Cayman 10483), berberine (Cayman 10006427), dasatinib (Cayman 11498), propranolol (Sigma-Aldrich P0884), aldosterone

(3) Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodesElifeDecember 23, 2025Stephen A Banse, Christine A Sedore, Anna L Coleman-Hulbert, Erik Johnson, Brian Onken, David Hall, Erik Segerdell, E Grace Jackson, Yuhua Song, Haley C Osman, et al.arecoline (Cayman 13662), everolimus (Cayman 11597), temsirolimus (Cayman 11590), erlotinib (Cayman 10483), berberine (Cayman 10006427), dasatinib (Cayman 11498), propranolol (Sigma-Aldrich P0884), aldosterone

(4) The Interconnection Between UbcH10, p53, and EGFR in Lung Cancer Cells and Their Involvement in Treatment ResponseGenes (Basel)March 30, 2025Cristina Quintavalle, Umberto Malapelle, Marco De Martino, Danilo Rocco, Alfredo Fusco, Francesco Pepe, Claudio Bellevicine, Francesco Esposito, Pierlorenzo Pallanteto the control group that did not receive treatment. Erlotinib was purchased from Cayman Chemical (#10483, Cayman Chemical, Ann Arbor, MI, USA) and was administered to the cells 24 h after transfection. Apoptosis

(5) Erlotinib regulates short-term memory, tau/Aβ pathology, and astrogliosis in mouse models of ADFrontiers in immunologyJanuary 1, 2024Lee HJ, Hwang JW, Kim J, Jo AR, Park JH, Jeong YJ, Jang JY, Kim SJ, Song JH, Hoe HS.approval no. IACUC-19-00049, IACUC-22-00044). Erlotinib treatment Erlotinib (Cayman Chemical, Cat no: 10483, Ann Arbor, MI, USA) was dissolved in dimethyl sulfoxide (DMSO) or vehicle (5% DMSO + 10% PEG + 20%

(6) Sublethal cytochrome c release generates drug-tolerant persister cellsCellSeptember 1, 2022Kalkavan H, Chen MJ, Crawford JC, Quarato G, Fitzgerald P, Tait SWG, Goding CR, Green DR.2143542-28-1 Paclitaxel,MCE,Cat# HY-B0015 RSL3,Selleck Chemicals,Cat# S8155 Irinotecan,MCE,Cat# HY-16562 Erlotinib,Cayman,Cat# 10483 Vemurafenib (PLX4032),Cayman,Cat# 10618 Raptinal,Millipore Sigma,Cat# SML1745 Digitonin,Sigma-Aldrich,Cat#

(7) Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer BiologyeLifeDecember 7, 2021Errington TM, Denis A, Allison AB, Araiza R, Aza-Blanc P, Bower LR, Campos J, Chu H, Denson S, Donham C, et al.densities. The next day fresh medium with various concentrations of erlotinib (Cayman Chemical, cat# 10483) or erlotinib HCl (LC Laboratories, cat# E-4007). Media was replaced every 3 days. Nine days after flasks

(8) Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoidsNature communicationsDecember 1, 2021Gong K, Guo G, Beckley NA, Yang X, Zhang Y, Gerber DE, Minna JD, Burma S, Zhao D, Akbay EA, et al.contamination using an e-Myco kit (Boca Scientific). Drugs For the in vitro experiments, Erlotinib (10483), Afatinib (11492), Osimertinib (16237), Thalidomide (14610), Prednisolone (20866), Dexamethasone (11015)

(9) Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma TreatmentCancers (Basel)August 20, 2021Christina Bothou, Ashish Sharma, Adrian Oo, Baek Kim, Pal Perge, Peter Igaz, Cristina L. Ronchi, Igor Shapiro, Constanze HantelBristol-Myers Squibb SA, Steinhausen, Switzerland), all diluted in medium. Moreover, we used erlotinib (#10483, Cayman, Ann-Arbor, MI, USA), linsitinib (#17708, Cayman), sorafenib (#10009644, Cayman), XAV-939 (#S1180,

(10) Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic RiskCell Reports MedicineAugust 25, 2020Mark R. Davies, Michael Martinec, Robert Walls, Roman Schwarz, Gary R. Mirams, Ken Wang, Guido Steiner, Andy Surinach, Carlos Flores, Thierry Lavé, et al.,Cayman Chemical,15007; CAS Number 25316-40-9 DULOXETINE,Roche,RO4500720-000-001 ERLOTINIB,Cayman Chemical,10483; CAS Number 183321-74-6 ERYTHROMYCIN,ICN Biomedicals,1890197; CAS Number 114-07-8 FLECAINIDE,Sigma-Aldrich,F-6777;

(11) Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cellsOncogeneFebruary 1, 2020Misek SA, Appleton KM, Dexheimer TS, Lisabeth EM, Lo RS, Larsen SD, Gallo KA, Neubig RR.from Sellekchem, Houston, TX, USA. Latrunculin B (#10010631), cytochalasin D (#11330), and erlotinib (#10483) were purchased from Cayman Chemical, Ann Arbor, MI, USA. Rho Inhibitor I (#CT04-A) was purchased from

(12) Evolutionarily conserved regulation of sleep by epidermal growth factor receptor signalingScience AdvancesNovember 13, 2019Daniel A. Lee et al.vehicle control, 0.1, 0.5, 1, 5, 10, 50, and 100 μM. Gefitinib (13166, Cayman Chemical) and erlotinib (10483, Cayman Chemical) were not soluble at 50 or 100 μM, and treatment of zebrafish with 10 μM of either

(13) Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-TKI-Mediated Anticancer Activity in NSCLCTranslational oncologyNovember 1, 2019Yang Z, Chan KI, Kwok HF, Tam KY.humidified atmosphere with 5% CO2 at 37°C in incubators. Erlotinib was purchased from Cayman Chemical (Cat#: 10483). Gefitinib was purchased from SelleckChem (Cat#: S1025). Anti-ADAM17 primary antibody was ordered from

(14) Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP DestabilizationCellSeptember 20, 2018Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, et al.ab174000 4-Methylumbelliferone,Sigma,Cat# M1381 Apigenin,Tocris,Cat# 12-271-0 A-769662,Tocris,Cat# 3336 Erlotinib,Cayman,Cat# 10483 PD 0325901,Sigma,Cat# PZ0162 SP600125,Tocris,Cat# 1496 OCT compound,Fisher Scientific,Cat # 23-730-571 "Hyaluronic acid binding protein, bovine nasal cartilage, biotinylated

(15) Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder CancerCellApril 5, 2018Lee SH, Hu W, Matulay JT, Silva MV, Owczarek TB, Kim K, Chua CW, Barlow LJ, Kandoth C, Williams AB, et al.Scientific,Cat#34577 Neratinib (HKI-272),Selleck Chemicals,Cat#S2150 Erlotinib,Cayman Chemical,Cat#10483 Sapitinib (AZD8931),Selleck Chemicals,Cat#S2192 PD-173074,Cayman Chemical,Cat#13032 Dovitinib,Cayman Chemical

(16) A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinibOncotargetDecember 1, 2017Nancy D. Ebelt, Tamer S. Kaoud, Ramakrishna Edupuganti, Sabrina Van Ravenstein, Kevin N. Dalby, Carla L. Van Den Bergsulfoxide (DMSO). Gefitinib was purchased from #H018 AK Scientific, Union City, CA, Erlotinib from #10483 Cayman Chemical, Ann Arbor, MI, and Neratinib from #52150 SelleckChem, Houston, TX. Epidermal Growth

(17) Registered report: A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulationseLifeFebruary 23, 2016Haven B, Heilig E, Donham C, Settles M, Vasilevsky N, Owen K, Reproducibility Project: Cancer Biology., Reproducibility Project Cancer Biology..cm dishes,Labware,Corning,430167,Original brand not specified. Erlotinib,Inhibitor,Cayman Chemical,10483,Replaces original obtained from MGH pharmacy DMSO,Chemical,Sigma-Aldrich,D8418,Not originally reported. RPMI 1640

(18) Loss of p120ctn causes EGFR-targeted therapy resistance and failurePloS oneJanuary 1, 0001"Landmesser ME, Raup-Konsavage WM, Lehman HL, Stairs DB."cells were treated with 5 μM gefitinib (#076091; Matrix Scientific, Columbia, SC), 10 μM erlotinib (#10483; Cayman Chemical; Ann Arbor, MI), or 10 nM cetuximab (#NBP2-75903; Novus Biologicals; Centennial, CO),

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Erlotinib from Cayman Chemical

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Cayman Chemical

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Erlotinib from Cayman Chemical

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