PTP1B Inhibitor from Santa Cruz Biotechnology, Inc.

Product Specs
ItemPTP1B Inhibitor
CompanySanta Cruz Biotechnology, Inc.
Price $226.00Supplier Page View Company Product Page
Catalog Numbersc-222227
Quantity5 mg
TypeBiochemical Reagents
Molecular Weight741.5

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Flavonoids from Elsholtzia ciliata restore redox electron flow and metabolic signaling via PTP1B inhibition in muscle and liver cellsJ Enzyme Inhib Med ChemMay 11, 2026Sang Seop Lee, Jang Hoon Kim, Kyonghwan Bang, Jin Yu, Yong Goo Kim, Sung Yeon Kim, Ik Soo Lee, Yung Choon Yoowell-established PTP1B inhibitor20, and the Santa Cruz PTP1B inhibitor (ScI; Santa Cruz Biotechnology, sc-222227) were used as positive controls. The IC50 values are presented in Table 1, and the dose–response curves

(2) DNA-PK-mediated phosphorylation of STAT6 establishes a non-canonical type 2 immunity axis to prevent macrophage senescenceNature CommunicationsFebruary 24, 2026Zhao Zhou, Xinmeng Li, Yushuang Wang, Long Liang, Chunyang Wang, Yongchang Sun, Dongmei Wu, Yifu Qiu#S8685), STING inhibitor H151 (1 μM, Selleck Chemicals, #S6652), PTP1B inhibitor (2 μM, Santa Cruz, #sc-222227), PU.1 inhibitor DB2313 (10 nM, MedChem Express, #HY-124629), EPAC inhibitor ESI-09 (10 μM, Selleck Chemicals

(3) Physical inactivity induces insulin resistance in plantaris muscle through protein tyrosine phosphatase 1B activation in miceFrontiers in physiologyJanuary 1, 2023Kakehi S, Tamura Y, Ikeda SI, Kaga N, Taka H, Nishida Y, Kawamori R, Watada H.

(4) PD-L1 tumor-intrinsic signaling and its therapeutic implication in triple-negative breast cancerJCI insightApril 22, 2021Chen C, Li S, Xue J, Qi M, Liu X, Huang Y, Hu J, Dong H, Ling K.

(5) Astragaloside IV inhibits protein tyrosine phosphatase 1B and improves insulin resistance in insulin-resistant HepG2 cells and triglyceride accumulation in oleic acid (OA)-treated HepG2 cellsJournal of ethnopharmacologyMarch 25, 2021Zhou X, Wang LL, Tang WJ, Tang B.

(6) PTP1B inhibitor alleviates deleterious microglial activation and neuronal injury after ischemic stroke by modulating the ER stress-autophagy axis via PERK signaling in microgliaAgingJanuary 20, 2021Zhu Y, Yu J, Gong J, Shen J, Ye D, Cheng D, Xie Z, Zeng J, Xu K, Shen J, et al.PTP1B for cerebral ischemic stroke treatment. MATERIALS AND METHODS Reagents The PTP1B inhibitor, sc-222227, was purchased from Santa Cruz Biotechnology, Inc. (Santa Cruz, CA, USA). The autophagy inhibitor, N(3)-methyladenine

(7) The HSV-1 mechanisms of cell-to-cell spread and fusion are critically dependent on host PTP1BPLoS pathogensMay 1, 2018Carmichael JC, Yokota H, Craven RC, Schmitt A, Wills JW.

(8) Serotonin suppresses β-casein expression via PTP1B activation in human mammary epithelial cellsBiochemical and biophysical research communicationsApril 22, 2016Chiba T, Maeda T, Sanbe A, Kudo K.

(9) A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammationJournal of neuroinflammationApril 19, 2016Song GJ, Jung M, Kim JH, Park H, Rahman MH, Zhang S, Zhang ZY, Park DH, Kook H, Lee IK, et al.

(10) 4-Hydroxynonenal activates Src through a non-canonical pathway that involves EGFR/PTP1BFree radical biology & medicineDecember 1, 2015Zhang H, Forman HJ.

(11) Sustained high protein-tyrosine phosphatase 1B activity in the sperm of obese males impairs the sperm acrosome reactionThe Journal of biological chemistryMarch 21, 2014Shi L, Zhang Q, Xu B, Jiang X, Dai Y, Zhang CY, Zen K.

(12) Differential erythropoietin action upon cells induced to eryptosis by different agentsCell biochemistry and biophysicsMarch 1, 2013Vota DM, Maltaneri RE, Wenker SD, Nesse AB, Vittori DC.

(13) Protein tyrosine phosphatase 1B deficiency ameliorates murine experimental colitis via the expansion of myeloid-derived suppressor cellsPloS oneJanuary 1, 2013Zhang J, Wang B, Zhang W, Wei Y, Bian Z, Zhang CY, Li L, Zen K.

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PTP1B Inhibitor Chemicals

PTP1B Inhibitor from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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PTP1B Inhibitor from Santa Cruz Biotechnology, Inc.

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