Description
A pan-HDAC inhibitor (Kis = 0.6-31 nM for HDAC1-11); inhibits growth in a panel of 37 human or mouse lung cancer cell lines, including SCLC, NSCLC, and mesothelioma cells (IC50s = 4-175, 5-310, and 5-470 nM, respectively); induces tumor regression in BK-T and RG-1 SCLC mouse xenograft models at 20 mg/kg i.p