Description
MSA-2, a potent and orally available non-nucleotide STING agonist, has EC50s of 8.3 and 24 uM for human STING isoforms WT and HAQ, respectively. MSA-2 shows antitumor activity and stimulates interferon-beta secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models