Description
An NSAID with anticancer activity; selective for COX-2 over COX-1 in canine DH82 monocyte/macrophage cells (IC50s = 3.53 and >51.2 µg/ml, respectively); inhibits fMLP- or A23187-induced calcium influx in human PMNLs; decreases protein levels of the transcription factors Sp1, Sp3, and Sp4 in PANC-1 and L3.6pl cells at 50 µM; inhibits proliferation of PANC-1, L3.6pl, and PANC-28 cells; decreases the viability of and induces apoptosis in MDA-MB-231 cells at 50 and 100 µM; reduces tumor growth in an MDA-MB-231 mouse xenograft model at 25 and 50 mg/kg; reduces carrageenan-induced paw edema in mice by 24% at 150 µmol/kg