Description
Isatin is an endogenous monoamine oxidase (MAO) inhibitor involved in stress and anxiety. Additionally, isatin inhibits alkaline phosphatase (ALP), nitric oxide (NO)-stimulated soluble guanylate cyclase, and other enzymes.An endogenous monoamine oxidase inhibitor.Application：Isatin can be used as a reactant to prepare:Phthalazinone derivatives.Spirooxindole derivatives.Agents against multidrug-resistant cells expressing P-glycoprotein.Thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.Triazole-isatine compounds as potential antibacterial and antifungal agents.Biologically relevant scaffolds such as spiro[indole-thiazolidinones].It can be a reactant for:Cascade reactions with heterocyclic ketene aminals.Knoevenagel condensation reactions.Isatin can also be used as a chromatographic spray reagent for amino acids, and also as a reference material in the preparation of indigo and Maya Blue. It is responsible for the yellow color exhibited by the "Maya Yellow" pigment.Isatin undergoes Pd(II)-catalyzed C-H addition by direct sp2/sp3 C-H bond activation to form 3-substituted-3-hydroxy-2-oxindoles. Isatin derivatives (bis-Schiff base) are synthesized by the condensation of the natural or synthetic isatins with hydrazine