Description
InformationCB-103 CB-103 is an orally active inhibitor of the Notch transcription activation complex. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts.TargetsNotchIn vitroCB-103 inhibits growth of Notch-addicted human T cell acute lymphoblastic leukemia cell lines through modulation of the Notch transcription complex.In vivoCB-103 function in vivo recapitulates genetic notch loss-of-function phenotypes without causing gut toxicity. CB-103 blocks tumor growth of GSI-resistant cancers.Cell Research(from reference)Cell lines：marrow mesenchymal stroma cells (MSCs), RPMI-8402 cells Concentrations：10 nM to 25 µM, 1 µM Incubation Time：3 days, 1 h, 4 h, 24 h