Description
MS159 is a potent nuclear receptor binding SET structural domain protein 2 ( NSD2 ) PROTAC degrader. MS159 inhibits the growth of tumour cells. MS159 is a useful chemical tool for exploring the role of NSD2 in health and disease.Appearance:SolidIn Vitro:MS159 (0.5-10 µM, 48 h) can induce the degradation of NSD2 protein in a time- and dose-dependent manner while the induced NSD2 degradation is reversible in 293FT cells. MS159 (2.5 µM, 72 h) can effectively degrade NSD2 as well as IKZF1 and IKZF3 in mBiological Activity:MS159 is a potent nuclear receptor binding SET structural domain protein 2 ( NSD2 ) PROTAC degrader. MS159 inhibits the growth of tumour cells. MS159 is a useful chemical tool for exploring the role of NSD2 in health and disease