Description
EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC 50 value of 2 uMIn VitroEN40 (10-1000 µM; 48 hours) shows inhibitory effecton ALDH3A1 activity and impairs A549 cell survival. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: A549 cells Concentration: 10 µM; 100 µM; 1000 µM Incubation Time: 48 hours Result: Inhibited A549 cells survival.In VivoEN40 (intraperitoneal injection; 50mg/kg; from 14 days; once per day) exerts strong anti-tumorigenic effects in established A549 tumor xenografts, shows good tolerability with no body weight loss in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: SCID mice with A549 cells Dosage: 50 mg/kg Administration: Intraperitoneal injection; 50mg/kg; from 14 days; once per day Result: Had strong anti-tumorigenic effects in tumor xenografts.Form:OilIC50& Target:IC50: 2 uM (ALDH3A1)