Ruxolitinib (INCB018424) from Aladdin Scientific

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Ruxolitinib (INCB018424)

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Description

INCB018424 is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.An inhibitor of JAK1, JAK2, and JAK3