Description
Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst 2 /sst 5 receptor partial agonist with IC 50 values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis researchIn VitroAngiopeptin (0.1 nM- 10 µM; for 1 h) TFA acts as a partial agonist (pEC 50 =6.57) with a maximum response of 423% at 3 µM on the release of tritium on CHO hsst 2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoAngiopeptin (20 and 50µg/kg; i.h.) TFA significantly inhibits neointimal formation. Angiopeptin (20 µg/kg; per day) TFA significantly inhibits coronary artery myointimal proliferation in cardiac allografts by appmximalely 50%. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 0.26 nM (sst2) and 6.92 nM (sst5)