Description
Aprocitentan-d 4 is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively.Appearance:SolidIC50& Target:ET A 3.4 nM (IC 50 ) ET A 6.7 (pA2) ET B 987 nM (IC 50 ) ET B 5.5 (pA2)Biological Activity:Aprocitentan-d 4 is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively