Description
NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) ( HY-125033 ) as a triphosphate form. NHC-triphosphate triammonium is a weak alternative substrate for the viral polymerase and can be iAppearance:SolidIn Vitro:In an intracellular metabolism assay, HCV replicon cells are treated with 10 µM 3 H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono-, di-, and triphosphate forms, anBiological Activity:NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) ( HY-125033 ) as a triphosphate form. NHC-triphosphate triammonium is a weak alternative substrate for the viral polymerase and can be i