DI-82 from MedChemExpress | Biocompare.com

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DI-82

Description

DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC₅₀^app of 27.8 nM and K_i^app of 9.2 nM. DI-82 has antitumor activity

Product Specs
ItemDI-82
CompanyMedChemExpress
Price $450.00Supplier Page View Company Product Page
Catalog NumberHY-136499
TypeChemical
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Quantity5 mg
Purity98.0%
Research AreaCancer

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(1) CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracilNature communicationsMarch 24, 2016Almqvist H, Axelsson H, Jafari R, Dan C, Mateus A, Haraldsson M, Larsson A, Martinez Molina D, Artursson P, Lundbäck T, et al.

(2) Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stabilityJournal of medicinal chemistryNovember 26, 2014Nomme J, Li Z, Gipson RM, Wang J, Armijo AL, Le T, Poddar S, Smith T, Santarsiero BD, Nguyen HA, et al.

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