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Protein Biochemistry
Chemicals and Reagents
Navtemadlin
Navtemadlin from MedChemExpress
Be the first to write a review!
Citations:
(5)
Supplier Page
Supplier Page from
MedChemExpress for
Navtemadlin
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Description
Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of
p53-MDM2
interaction, with an
IC
50
of 0.6 nM. Navtemadlin binds to MDM2 with a
K
d
of 0.045 nM
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Navtemadlin
Company
MedChemExpress
Price
$85.00
Supplier Page
View Company Product Page
Catalog Number
HY-12296
Quantity
1 mg
Applications
Bioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity
99.61%
Type
Chemical
Research Area
Cancer
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MedChemExpress
1 Deer Park Drive, Suite F
MONMOUTH JUNCTION
,
NJ
08852
United States
Phone
: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910
Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com
Company Profile
Website:
medchemexpress.com
Citations (5)
(1)
PROTAC-Mediated Targeted Degradation of MDM2 Induces Tumor-Suppressive Signaling in Osteosarcoma Cells
Cells
March 5, 2026
Yeongji Kim, Jin-Woo Kim, Junwon Choi, Jinhyeong Kim, Soyeon Park, Wonji Choi, Hyunju An, Jinman Kim, Minsup Kim, Sujin Choi,
et al.
No.,Solvent 1,
Sigma
,Nutlin-3,
N6287
,DMSO 2,MCE,RG7112 (RO5045337),
HY-15676
,DMSO 3,
MCE
,Idasanutlin (RG7388),
HY-15676
,DMSO 4,MCE,
Navtemadlin
(AMG-232),
HY-12296
,DMSO 5,
MCE
,
Alrizomadlin
(APG-115),
HY101518
,DMSO 6,
MCE
,NVP-CGM097 (CGM097),
HY-15954
,DMSO 7,
MCE
,
Siremadlin
(2)
CeDaD-a novel assay for simultaneous tracking of cell death and division in a single population
Cell Death Discov
March 4, 2025
Lukas Nöltner, Kurt Engeland, Robin Kohler
containing 5x concentrated DMSO (
1:200
) with or without dissolved compounds, namely AMG 232 (
MedChemExpress
,
HY-12296
),
YKL-5-124
(
MedChemExpress
,
HY-101257
), and volasertib (
MedChemExpress
,
HY-12137
) of varying concentrations
(3)
Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations
Nat Genet
January 7, 2025
Julianne S. Funk, Maria Klimovich, Daniel Drangenstein, Ole Pielhoop, Pascal Hunold, Anna Borowek, Maxim Noeparast, Evangelos Pavlakis, Michelle Neumann, Dimitrios-Ilias Balourdas,
et al.
cat. no. 444153), 1 µM MI-773 (
Selleckchem
, cat. no.
S7649
), 750 nM AMG 232 (
MedChemExpress
, cat. no.
HY-12296
) or the respective volume of DMSO (Carl Roth, cat. no. 4720) as solvent control for 8 d. For irradiation
(4)
The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents
Molecular cancer therapeutics
March 1, 2015
Canon J, Osgood T, Olson SH, Saiki AY, Robertson R, Yu D, Eksterowicz J, Ye Q, Jin L, Chen A,
et al
.
(5)
Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer
Journal of medicinal chemistry
August 14, 2014
Rew Y, Sun D.
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Navtemadlin from MedChemExpress
Supplier Page
View Company Product Page
$85.00
Product Specs
Company Info
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Reviews
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