OSMI-4 from MedChemExpress

Product Specs
ItemOSMI-4
CompanyMedChemExpress
Price $715.00Supplier Page View Company Product Page
Catalog NumberHY-114361
TypeChemical
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Quantity10 mM * 1 mL
Purity99.69%
Research AreaMetabolic Disease

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(1) Mechanoresponsive modulation of nuclear pore complex structure and function by O -GlcNAcbioRxivJuly 8, 2026Sunandini Chandra, Kimberly J. Morgan, William L. Chadwick, Megan C. King, C. Patrick Luskmodulate whole cellular protein GlcNAcylation levels, cells were treated with either 10 μM OSMI-4 (HY-114361; MedChemExpress) to inhibit OGT or 3 μM TMG (13237; Cayman Chemical) to inhibit OGA for 24 h prior to

(2) Hexosamine biosynthesis drives hemocyanin O-GlcNAcylation to potentiate antibacterial immunity in shrimpJournal of Biological ChemistryJuly 1, 2026Qian Feng, Maoshuai Fu, Wei Wang, Tingchu Wu, Junjie Nie, Zhihong Zheng, Yongzhen Zhao, Jude Juventus Aweya, Yueling Zhangμg/ml; GFAT inhibitor; MedChemExpress, HY-108357), OSMI4 (500 μg/ml; OGT inhibitor; MedChemExpress, HY-114361), or Thiamet G (100 μg/ml; OGA inhibitor; MedChemExpress, HY-12588). Control shrimp were injected with

(3) SlSEC1- and SlSPY-mediated O -glycosylation stabilizes the transcription factor SlNOR to promote tomato fruit ripeningThe Plant CellJune 2, 2026Yu-Di Wu, Ruo-Han Ou, Can Yang, Tong-Hao Cui, Qian-Yu Wang, Yu-Yang Mei, Jia-Fei Qian, Yi-Long Liu, Yuan-Jiang Pan, Zhi-Ping Deng, et al.modifications. IMG stage fruits were injected into the central columella with 50 μL of 0.5 mM OSMI-4 (MCE, HY-114361, USA) as SEC inhibitor (Martin et al. 2018), 0.5 mM TMC647055 choline salt (MCE, HY-15591A, USA) as

(4) O-GlcNAcylation promotes angiogenic transdifferentiation to reverse vascular ischemiaNature Cardiovascular ResearchJuly 4, 2025Shuang Li, Alexander J. Lu, Eric S. Nagueh, Yanqiang Li, Michael Graber, Kaylee N. Carter, Elisa Morales, Crystina L. Kriss, Kaifu Chen, Junchen Liu, et al.knockout of OGA and OGT. Hindlimb ischemia surgery was performed one week post-final injection. OSMI-4 (HY-114361, MedChemExpress) was dissolved in 90% corn oil and 10% DMSO and injected intraperitoneally (4 mg/kg)

(5) JUNB O‐GlcNAcylation‐Mediated Promoter Accessibility of Metabolic Genes Modulates Distinct Epithelial Lineage in Pulmonary FibrosisAdvanced ScienceDecember 15, 2024Marie‐Therese Bammert, Meshal Ansari, Leoni Haag, Zuhdi Ahmad, Victoria Schröder, Joseph Birch, Diana Santacruz, Werner Rust, Coralie Viollet, Benjamin Strobel, et al.(Supporting Information). To block OGT in AOs a commercially available inhibitor (OSMI‐4, MedChemExpress #HY‐114361[ 63 ]) was used in 10 µM concentration for 7 days. 2D Cultivation of Primary Cells Healthy human

(6) Systematic analysis of the impact of phosphorylation and O-GlcNAcylation on protein subcellular localizationCell ReportsJuly 14, 2023Senhan Xu, Suttipong Suttapitugsakul, Ming Tong, Ronghu WuTools,Cat#1086; CAS 653600-56-7 Thiamet-G,Cayman chemical,Cat#13237; CAS 1009816-48-1 OSMI-4,MedChemExpress,Cat#HY-114361 "cOmplete™, Mini, EDTA-free protease inhibitor cocktail",Sigma-Aldrich,Cat# 11836170001 Benzonase®Nuclease,Sigma-Aldrich,Cat#E1014 Photocleavable

(7) Inhibiting Hyper-O-GlcNAcylation of c-Myc accelerate diabetic wound healing by alleviating keratinocyte dysfunctionBurns & traumaJanuary 1, 2021Zhang J, Yang P, Liu D, Gao M, Wang J, Yu T, Zhang X, Liu Y.for 24 h with compounds including OGA inhibitor (Thiamet G, HY-12588, MCE) and OGT inhibitor (OSMI-4, HY-114361, MCE) at a concentration of 10 μM. Differentiation of HaCaT cells was induced by increasing the calcium

(8) Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase InhibitorsJournal of the American Chemical SocietyOctober 24, 2018Martin SES, Tan ZW, Itkonen HM, Duveau DY, Paulo JA, Janetzko J, Boutz PL, Törk L, Moss FA, Thomas CJ, et al.

(9) O-GlcNAcylation regulates OTX2's proteostasisiScienceJanuary 1, 0001"Wulff-Fuentes E, Boakye J, Kroenke K, Berendt RR, Martinez-Morant C, Pereckas M, Hanover JA, Olivier-Van Stichelen S."01810 PUGNAc,Millipore Sigma,Cat# A7229 Doxycycline,TCI Chemicals,Cat# D4116 OSMI4,MedChemExpress,Cat# HY-114361 DRB,Millipore Sigma,Cat# D1916 Rapamycin,Cell Signaling,Cat# 9904 DSP,Pierce,Cat# A35393 Phos binding

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OSMI-4 from MedChemExpress

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OSMI-4 from MedChemExpress

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