Description
A TLR3, TLR8, and TLR9 receptor agonist; selectively induces NF-κB activation in HEK293 cells expressing recombinant human TLR3, TLR8, or TLR9 (EC50s = 4.8, 13.45, and 5.66 µM, respectively) over HEK293 cells expressing recombinant human TLR2, TLR4, TLR5, or TLR7 (EC50s = >100 µM for all); induces TNF-α, IL-6, and IL-8 production in THP-1 cells from 5-40 µM; inhibits the growth of HeLa cells (IC50 = 2.71 µM)