Description
An active metabolite of buspirone; binds to 5-HT1A in rat hippocampus and dorsal raphe (EC50s = 4 and 1 µM, respectively); a dopamine D2, D3, and D4 receptor antagonist (IC50s = 3.1, 4.9, and 0.85 µM, respectively); inhibits OCT1, OCT2, and OCT3 in S2 proximal tubule cells expressing the human transporters