Description
A RyR1-FKBP12 protein-protein interaction stabilizer; reduces neurite growth and length in isolated spinal cords from neonatal rats at 50 and 100 µM; decreases RyR1 and FKBP12 dissociation in isolated mouse muscle fibers; ex vivo, reduces exercise-induced calcium leakage in mouse muscle fibers; decreases muscle fatigue and increases treadmill running time in mice; increases grip strength and reduces exercise-induced muscle damage in a dystrophin DMD-/- knockout mouse model of Duchenne muscular dystrophy