Description
A GSK3α inhibitor (IC50 = 66 nM); selective for GSK3α over GSK3β (IC50 = 515 nM); inhibits GSK3α autophosphorylation in U937 cells at 10 and 20 µM; impairs colony formation by various AML cells; inhibits leukemia development in secondary recipient mice in an MLL-AF9 mouse syngeneic tumor model at 30 mg/kg