Description
CS-526 is a proton pump inhibitor. The inhibitory mechanism of CS-526 on H+, K+-ATPase was a competitive antagonism to the K+ binding site of H+, K+-ATPase, and it was also a reversible inhibition. CS-526 has a potent antisecretory effect on gastric acid secretion without rebound gastric hypersecretion. CS-526 inhibited acute gastric mucosal lesions. CS-526 inhibited histamine-stimulated gastric acid secretion in a dose- and retention time-dependent manner