Description
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 <10nM and it is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects[1][2]. Balixafortide blocks beta-arrestin recruitment and calcium flux with IC50s <10nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7