Description
SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor alpha (ERalpha) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERalpha protein (IC50=0.097uM). SNIPER(ER)-87 preferentially recruits XIAP to ERalpha in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERalpha degradation[1][2]