Description
CBS-3595 is a potent and dual Inhibitor of p38alpha MAPK/PDE-4 with a superior profile regarding its anti-inflammatory effects. CBS-3595 features moderate inhibition of p38alpha MAPK and PDE-4 in the higher nanomolar range in combination with excellent kinetic properties and low plasma protein binding contributing to the outstanding results of the efficacy experiments performed in animal models and Humans. The inhibition of TNFalpha release was achieved at dose levels and systemic concentrations that were well below levels related to toxicity