Description
An ionizable cationic lipid; has been used in the generation of LNPs for the delivery of CRISPR complementary sgRNA and Cas9 mRNA for genome editing in vitro and in vivo; LNPs containing BAMEA-O16B encapsulating Cas9 mRNA and sgRNAs targeting PCSK9 accumulate in the liver and decrease serum PCSK9 levels in mice