RO4987655 from MedChemExpress | Biocompare.com

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RO4987655

Description

RO4987655 is an orally active and highly selective MEK inhibitor with an IC₅₀ of 5.2 nM for inhibition of MEK1/MEK2

Product Specs
ItemRO4987655
CompanyMedChemExpress
Price $220.00Supplier Page View Company Product Page
Catalog NumberHY-14719
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.01%
TypeChemical
Molecular Weight565.28
FormulaC₂₀H₁₉F₃IN₃O₅
Research AreaCancer

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(1) Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [(18)F] FDG-PET imaging combined with proteomic approachesEJNMMI researchDecember 1, 2014Tegnebratt T, Ruge E, Bader S, Ishii N, Aida S, Yoshimura Y, Ooi CH, Lu L, Mitsios N, Meresse V, et al.

(2) The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of CH4987655 in healthy volunteers: target suppression using a biomarkerClinical cancer research : an official journal of the American Association for Cancer ResearchDecember 1, 2009Lee L, Niu H, Rueger R, Igawa Y, Deutsch J, Ishii N, Mu S, Sakamoto Y, Busse-Reid R, Gimmi C, et al.

(3) [Ultrastructure of the cerebral cortex neurons in atherosclerotic dementia]Morfologiia (Saint Petersburg, Russia)January 1, 2001Popova EN.

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