Palbociclib from MedChemExpress

Product Specs
ItemPalbociclib
CompanyMedChemExpress
Price $60.00Supplier Page View Company Product Page
Catalog NumberHY-50767
Quantity5 mg
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.94%
TypeChemical
Molecular Weight447.53
Molecule NamePalbociclib
FormulaC24H29N7O2
Research AreaCancer

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(1) MKRN2-Mediated Degradation of IGF2BP3 Suppresses MYC and Enhances CDK4/6 Inhibitor Sensitivity in Bladder CancerCancers (Basel)July 6, 2026Qi Pan, Qing Shi, Yubo Zhao, Tianxi Yu, Shiyu Bai, Haoran Zhu, Wei Zhang, Yaowei Li, Ziyi Liu, Haonan Li, et al.IGF2BP3/MKRN2-OE, and IGF2BP3/MKRN2-OE + palbociclib. Palbociclib (MedChemExpress, Shanghai, China, HY-50767, 75 mg/kg) was administered once daily by oral gavage. Body weight and tumor volume (length × width2/2)

(2) Virus-host interactome reveals host cellular pathways perturbed by tick-borne encephalitis virus infectioniScienceJune 19, 2026Liyan Sui, Ying-Hua Zhao, Heming Wang, Hongmiao Chi, Hanxi Xie, Tian Tian, Wenfang Wang, Mucuo Zhu, Naicui Zhai, Zhixia Song, et al.proteins" ,, Thymidine,Selleck,S4803 Nocodazole,Selleck,S2775 Chrysin,Selleck,S2281 Palbociclib,MCE,HY50767 C646,Selleck,S7152 CPI-637,Selleck,S8190 WM-1119,Selleck,S8776 WM-3835,Selleck,S9805 Chrysin,Selleck,S2281 Sunitinib,APExBio,B1045 Dequalinium Chloride

(3) Targeting RAC1 in glioblastoma: prognostic value, immune landscape, and small molecule therapeutic potentialFrontiers in OncologyJune 18, 2026Qionghui Wu, Shanlin Chen, Xiaodong Xie, Xinli Feng, Zhenchang Zhang, Gang Suconcentrations of RAC1 inhibitor NSC23766(Cat. No. HY-15723, MedChemExpress) or Palbociclib (Cat. No. HY-50767, MedChemExpress) at 37 degrees C in an atmosphere of 5% CO2 for either 24 or 48 hours. Subsequently,

(4) Human iPSC-derived GABAergic interneuron transplantation restores circuit balance and cognitive function in an Alzheimer's disease modelAlzheimers DementApril 27, 2026Xinzhe Zhang, Gaojie Wang, Haodong Chen, Ye Sun, Ziteng Wangliu, Lijing Wang, Miao Sun, Qing Liu, Xue Zhanginhibitors (DAPT 10 µM; HY‐13027, MCE) and cyclin‐dependent kinase (CDK) inhibitors (PD0332991 2 µM; MCE, HY‐50767) were introduced to induce cell cycle exit in the cells during this stage. Ultimately, cells were collected

(5) Rapid photo-crosslinking in living cells reveals protein-nucleic acid dynamics on a timescale of minutesNucleic Acids ResApril 21, 2026Jakob Trendel, Polina Prokofeva, Zhuo Angel Chen, Lukas Horn, Simon Trendel, Mirea Mema, Marchel Stuiver, Juri Rappsilber, Bernhard KusterEN300-28319299). To this end, 10 µl of 100 mM palbociclib in water (CAS 571190-30-2, MedchemExpress, HY-50767) was mixed with 11 µl of 100 mM photo-click freshly prepared in water, 1 µl of triethylamine was added,

(6) The E3 ligase β-TRCP1 earmarks OTUD3 for destruction to fine-tune cGAS activationJournal of Biological ChemistryApril 17, 2026Jianfeng Chen, Smaran Sivashankar, Ying Wang, Pengda Liu(HY-19323), KU-55933 (HY-12016), VE-822 (HY-13902), SCH772984 (HY-50846), MK2206 (HY-108232), Palbociclib (HY-50767), BKM120 (HY-70063), Torin 2 (HY-13002), Rapamycin (HY-10219), Dasatinib (HY-10181), and Sunitinib (HY-10255A)

(7) Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaksMolecular CellApril 2, 2026Shibo Li, Yuqin Zhao, Youhang Li, Sameer Bikram Shah, Yanmeng Shi, Tran Nguyen, Zi Wang, Chia-Yu Chang, Anagh Ray, Te-Hsuan Bu, et al.HY-N0565 Mirin,MCE,Cat# HY-19959 ART558,MCE,Cat# HY-141520 VE822,MCE,Cat# HY-13902 Palbociclib,MCE,Cat# HY-50767 cOmplete proteinase inhibitors,Roche,Cat# 11697498001 T4 DNA polymerase,NEB,Cat# M0203 T4 PNK,NEB,Cat#

(8) GPER1 reduces skin inflammation by inhibiting keratinocyte proliferationCell Death DiscoveryMarch 21, 2026Natalia Pérez-Escudero, Isabel Cabas, Raúl Corbalán-Vélez, Teresa Martínez-Menchón, Belén Ferri, María L. Cayuela, Diana García-Moreno, Alfonsa García-Ayala, Victoriano MuleroLarvae were treated from 24 hpf to 72 hpf with either the CDK4/CDK6 inhibitor Palbociclib (10 µM, #HY-50767, MCE) or with the GPER1 agonist G-1 (1, 0.5, 0.1 and 0.01 µM, #415919-74-3, Sigma-Aldrich) by bath immersion

(9) RPA-independent activation of the ATR/CHK1 pathwayProceedings of the National Academy of SciencesFebruary 10, 2026Min Huang, Dandan Zhu, Junjie Chen(cat. no. S8843) were purchased from Selleck Chemicals. The CDK4/6 inhibitor Palbociclib (cat. no.: HY-50767) and CHK1 inhibitor Rabusertib (cat. no. HY-14720) were purchased from MedChemExpress (MCE). dTAGv-1-NEG

(10) Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular CarcinomaAdvanced ScienceFebruary 1, 2026Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, et al.(HY‐N2329), chlorpromazine (HY‐12708), dynasore (HY‐15304), N‐acetylcysteine (HY‐B0215), palbociclib (HY‐50767) were purchased from MedChemExpress (MCE, USA). Doxorubicin (S1208), z‐VAD‐fmk (S7023) were obtained

(11) CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 inductionNature CommunicationsJanuary 22, 2026Linjie Luo, Yan Wang, Tuyen Bui, Xiaoting Jiang, Mei-Kuang Chen, Xiayu Rao, Sepideh Mohammadhosseinpour, Mi Li, Serena Kim, Rachel Y. Kim, et al.single drug at the indicated concentrations25,28. In vitro treatments with single agents palbociclib (HY-50767, MCE), abemaciclib (HY-16297A, MCE), ribociclib (HY-15777, MCE), upadacitinib (HY-19569, MCE), abrocitinib

(12) Loss of FAT1 drives cyclophosphamide resistance in breast cancer via the Wnt/β-Catenin pathwayInt J Biol SciJanuary 1, 2026Lijing Zhong, Dongyan Cao, Chen Zheng, Liyi Zhang, Yuxuan Xu, Shasha Zhao, Xiao Liu, Guiying Wei, Gengming Niu, Heming Xu, et al.this study included: Doxorubicin (Shyuany, 25316-40-9), Olaparib (MCE, HY-10162), Palbociclib (MCE, HY-50767) and Phosphoramide mustard cyclohexanamine (active metabolite of CTX; MCE, HY-137316A). For cell lines,

(13) Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancereLifeDecember 29, 2025Jessica Armand, Sungsoo Kim, Kibum Kim, Eugene Son, Minah Kim, Kevin Kalinsky, Hee Won YangS1191) were dissolved in DMSO (Sigma-Aldrich, D2438). For in vivo studies, palbociclib (MedChemExpress, HY-50767), ribociclib (MedChemExpress, HY-15777), and abemaciclib (MedChemExpress, HY-16297A) were prepared in

(14) Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancerElifeDecember 29, 2025Jessica Armand, Sungsoo Kim, Kibum Kim, Eugene Son, Minah Kim, Kevin Kalinsky, Hee Won YangS1191) were dissolved in DMSO (Sigma-Aldrich, D2438). For in vivo studies, palbociclib (MedChemExpress, HY-50767), ribociclib (MedChemExpress, HY-15777), and abemaciclib (MedChemExpress, HY-16297A) were prepared in

(15) CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screenNPJ Breast CancerDecember 3, 2025Nealia C. House, Maxine M. Chen, Sima Khazaei, Victoria Brown, Philip Ramsden, David H. Peng, Sydney Moore, Liang Yuan, Rentian Wu, Fangyang Wang, et al.(HY-13636), or XIROMED (NDC 70700-284-98). PF-07104091 (HY-137894A), INX-315 (HY-162001), palbociclib (HY-50767), abemaciclib (HY-16297A), RO-3306 (HY-12529), roniciclib (HY-13914), azenosertib (HY-132295), berzosertib

(16) Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seedingThe EMBO journalDecember 1, 2025Simonetti F, Zhong W, Hutten S, Uliana F, Schifferer M, Rezaei A, Ramirez LM, Hochmair J, Sankar R, Gopalan A, et al.Scientific,52887 Hoechst 33342,Thermo Scientific,H3570 Doxycycline,Sigma,D9891 Palbociclib,MedChemExpress,HY-50767 Ni-NTA agarose beads,Qiagen,30210 Ceramic beads,Precellys,P000918LYSK0-A MWCO 30 Amicon ultra centrifugal filters

(17) PIK75 effectively reverses PI3K‒AKT activation caused by palbociclib resistance and synergistically inhibits the progression of esophageal squamous cell carcinomaScientific ReportsNovember 28, 2025Yaning Zhao, Luxi Li, Yu Jiang, Yujiao Sun, Yi Xu, Xinyi Ye, Fangming Zhang, Fenxia Zhu, Yunzhi Pan, Sai Magroups (n = 8) based on the average tumor volume: the control group, Pal group (100 mg/kg palbociclib, HY-50767, MCE), PIK group (10 mg/kg PIK75, HY-107834, MCE), and two-drug combination group (75 mg/kg palbociclib

(18) CENcyclopedia: dynamic landscape of kinetochore architecture throughout the cell cycleNat CommunAugust 18, 2025Yu-Chia Chen, Ece Kilic, Evelyn Wang, Will Rossman, Aussie Suzuki2.5 or 5 μΜ STLC (Sigma-Aldrich, 164739), 10 μΜ ZM447439 (MCE, HY-10128), or 1 μΜ Palbociclib (MCE, HY-50767). 500 μΜ of Auxin (Sigma-Aldrich, 12886) was used for CENP-C-AID RPE1 cells and Dsn1-AID RPE1 cells.

(19) Optochemical control of G1 cell cycle by regulating CDK4/6 degradationiScienceAugust 6, 2025Tianyi Wang, Yaming Zhang, Yuwei Liu, Lichao Wang, Lijun Liu, Weiping Wang808260 "[dimethylamino-(3-oxidotriazolo[4,5-b]pyridin-3-ium-1-yl)methylidene]-dimethylazanium; hexafluorophosphate",MCE,Cat# HY-Y1703 Palbociclib,MCE,Cat# HY-50767 MTT,MCE,Cat# HY-15924 Puromycin,GoldBio,Cat# P-600-100 RIPA buffer,Thermo Scientific,Cat# 89900 Clarity

(20) The Non‐Canonical ChREBPα Activity Suppresses the Activation of Hepatic Stellate Cells and Liver Fibrosis by Antagonizing TGF‐β‐E2F1 AxisAdvanced ScienceJune 23, 2025Jian Zhang, Yuee Zhao, Gauthami Pulivendala, Qing Zhang, Liangyou Rui, Jiashi Gao, Huiwen Wang, Gary Zhang, Alli Nuotio‐Antar, Xin Tong, et al.liver fibrosis in vitro. SIS3 (3 µM, HY‐13013, MCE, US) was used to inhibit SMAD3, Palbociclib (1 µm, HY‐50767, MCE, US) to inhibit CDK4, MK‐2206 (65 nm, HY‐10358, MCE, US) to inhibit AKT, PD18416 (100 nm, HY‐10174,

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Palbociclib from MedChemExpress

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Palbociclib from MedChemExpress

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